Leukemogenesis by CBF oncoproteins

A. D. Friedman

doi:10.1038/sj.leu.2401590

Leukemogenesis by CBF oncoproteins

A. D. Friedman

School of Medicine

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

The AML1 and CBFβ subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFβ-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.

Original language	English (US)
Pages (from-to)	1932-1942
Number of pages	11
Journal	Leukemia
Volume	13
Issue number	12
DOIs	https://doi.org/10.1038/sj.leu.2401590
State	Published - 1999

Keywords

AML1-ETO
AML1-MDS1/EVI1
CBF
CBFβ-SMMHC
TEL-AML1

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/sj.leu.2401590

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title = "Leukemogenesis by CBF oncoproteins",

abstract = "The AML1 and CBFβ subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFβ-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.",

keywords = "AML1-ETO, AML1-MDS1/EVI1, CBF, CBFβ-SMMHC, TEL-AML1",

author = "Friedman, {A. D.}",

note = "Funding Information: ADF is a Leukemia Society of America Scholar, and his work on CBF oncoproteins is supported by grant HL51388 from the National Institutes of Health.",

year = "1999",

doi = "10.1038/sj.leu.2401590",

language = "English (US)",

volume = "13",

pages = "1932--1942",

journal = "Leukemia",

issn = "0887-6924",

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T1 - Leukemogenesis by CBF oncoproteins

AU - Friedman, A. D.

N1 - Funding Information: ADF is a Leukemia Society of America Scholar, and his work on CBF oncoproteins is supported by grant HL51388 from the National Institutes of Health.

PY - 1999

Y1 - 1999

N2 - The AML1 and CBFβ subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFβ-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.

AB - The AML1 and CBFβ subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFβ-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.

KW - AML1-ETO

KW - AML1-MDS1/EVI1

KW - CBF

KW - CBFβ-SMMHC

KW - TEL-AML1

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U2 - 10.1038/sj.leu.2401590

DO - 10.1038/sj.leu.2401590

M3 - Review article

C2 - 10602413

AN - SCOPUS:0032760819

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SP - 1932

EP - 1942

JO - Leukemia

JF - Leukemia

SN - 0887-6924

IS - 12

ER -

Leukemogenesis by CBF oncoproteins

Abstract

Keywords

ASJC Scopus subject areas

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