Abstract
The AML1 and CBFβ subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFβ-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1932-1942 |
| Number of pages | 11 |
| Journal | Leukemia |
| Volume | 13 |
| Issue number | 12 |
| DOIs | |
| State | Published - Jan 1 1999 |
Keywords
- AML1-ETO
- AML1-MDS1/EVI1
- CBF
- CBFβ-SMMHC
- TEL-AML1
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research