Leukemogenesis by CBF oncoproteins

Research output: Contribution to journalReview article

Abstract

The AML1 and CBFβ subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFβ-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.

Original languageEnglish (US)
Pages (from-to)1932-1942
Number of pages11
JournalLeukemia
Volume13
Issue number12
DOIs
StatePublished - Jan 1 1999

Keywords

  • AML1-ETO
  • AML1-MDS1/EVI1
  • CBF
  • CBFβ-SMMHC
  • TEL-AML1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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