Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1

Sun Don Kim, Jia Lie Liu, Tony Roscioli, Michael F. Buckley, Garima Yagnik, Simeon A. Boyadjiev, Jinoh Kim

Research output: Contribution to journalArticle

Abstract

Fibroblast growth factor receptors (FGFRs) play critical roles in craniofacial and skeletal development via multiple signaling pathways including MAPK, PI3K/AKT, and PLC-γ. FGFR-mediated signaling is modulated by several regulators. Proteins with leucine-rich repeat (LRR) and/or immunoglobulin (IG) superfamily domains have been suggested to interact with FGFRs. In addition, fibronectin leucine-rich repeat transmembrane protein 3 (FLRT3) has been shown to modulate the FGFR-mediated signaling via the fibronectin type III (FNIII) domain. Therefore proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs.

Original languageEnglish (US)
Pages (from-to)1516-1521
Number of pages6
JournalFEBS Letters
Volume586
Issue number10
DOIs
StatePublished - May 21 2012
Externally publishedYes

Fingerprint

Fibroblast Growth Factor Receptors
Leucine
Modulators
Immunoglobulins
Fibronectins
Proteins
Programmable logic controllers
Phosphatidylinositol 3-Kinases
Immunoglobulin Domains
leucine-rich repeat proteins

Keywords

  • Craniofacial development
  • ER export
  • FGF-signaling
  • FGFR regulation
  • Non-syndromic craniosynostosis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Kim, S. D., Liu, J. L., Roscioli, T., Buckley, M. F., Yagnik, G., Boyadjiev, S. A., & Kim, J. (2012). Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. FEBS Letters, 586(10), 1516-1521. https://doi.org/10.1016/j.febslet.2012.04.010

Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. / Kim, Sun Don; Liu, Jia Lie; Roscioli, Tony; Buckley, Michael F.; Yagnik, Garima; Boyadjiev, Simeon A.; Kim, Jinoh.

In: FEBS Letters, Vol. 586, No. 10, 21.05.2012, p. 1516-1521.

Research output: Contribution to journalArticle

Kim, SD, Liu, JL, Roscioli, T, Buckley, MF, Yagnik, G, Boyadjiev, SA & Kim, J 2012, 'Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1', FEBS Letters, vol. 586, no. 10, pp. 1516-1521. https://doi.org/10.1016/j.febslet.2012.04.010
Kim SD, Liu JL, Roscioli T, Buckley MF, Yagnik G, Boyadjiev SA et al. Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. FEBS Letters. 2012 May 21;586(10):1516-1521. https://doi.org/10.1016/j.febslet.2012.04.010
Kim, Sun Don ; Liu, Jia Lie ; Roscioli, Tony ; Buckley, Michael F. ; Yagnik, Garima ; Boyadjiev, Simeon A. ; Kim, Jinoh. / Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1. In: FEBS Letters. 2012 ; Vol. 586, No. 10. pp. 1516-1521.
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