Abstract
Fibroblast growth factor receptors (FGFRs) play critical roles in craniofacial and skeletal development via multiple signaling pathways including MAPK, PI3K/AKT, and PLC-γ. FGFR-mediated signaling is modulated by several regulators. Proteins with leucine-rich repeat (LRR) and/or immunoglobulin (IG) superfamily domains have been suggested to interact with FGFRs. In addition, fibronectin leucine-rich repeat transmembrane protein 3 (FLRT3) has been shown to modulate the FGFR-mediated signaling via the fibronectin type III (FNIII) domain. Therefore proteins with LRR, IG, and FNIII are candidate regulators of the FGFRs. Here we identify leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) as a regulator of the FGFRs.
Original language | English (US) |
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Pages (from-to) | 1516-1521 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 586 |
Issue number | 10 |
DOIs | |
State | Published - May 21 2012 |
Externally published | Yes |
Keywords
- Craniofacial development
- ER export
- FGF-signaling
- FGFR regulation
- Non-syndromic craniosynostosis
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Genetics
- Molecular Biology
- Structural Biology