Leucine-rich glioma-inactivated protein 1 antibody encephalitis: A case report

Yunis Mayasi, Deepak Takhtani, Neeta Garg

Research output: Contribution to journalArticlepeer-review


Objective: To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated encephalitis. Methods: The clinical and ancillary data and brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed. Results: The diagnosis of LGI1 antibody-associated autoimmune encephalitis was based on the typical clinical presentation of seizures, psychiatric symptoms, and memory loss as well as negative diagnostic testing for cancer; the diagnosis was confirmed by positive LGI1 antibody. The patient responded favorably to treatment with IV immunoglobulin and continues to do well. Conclusion: LGI1 antibody-associated encephalitis has increasingly been recognized as a primary autoimmune disorder with good prognosis and response to treatment.

Original languageEnglish (US)
Article numbere51
JournalNeurology: Neuroimmunology and NeuroInflammation
Issue number4
StatePublished - Dec 2014
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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