TY - JOUR
T1 - Leu-enkephalin Impairs Memory of an Appetitive Maze Response in Mice
AU - Linden, David
AU - Martinez, Joe L.
PY - 1986/2/1
Y1 - 1986/2/1
N2 - Leu-enkephalin (300 μg/kg) impaired memory of a Y-maze response in mice when the animals were trained to obtain food in one arm of the maze. The dose-response function was U-shaped, with neither 100 nor 600 μg/kg having any effect. Des-Tyr-Leu-enkephalin, a nonopioid peptide, had no effect at doses equimolar to the leu-enkephalin. Finally, the leu-enkephalin (300 μg/kg) was without effect if the drug injection was delayed 90 min. The results show that leu-enkephalin affects appetitive conditioning in much the same way as avoidance conditioning, a finding that suggests that leu-enkephalin may generally influence learning and memory.
AB - Leu-enkephalin (300 μg/kg) impaired memory of a Y-maze response in mice when the animals were trained to obtain food in one arm of the maze. The dose-response function was U-shaped, with neither 100 nor 600 μg/kg having any effect. Des-Tyr-Leu-enkephalin, a nonopioid peptide, had no effect at doses equimolar to the leu-enkephalin. Finally, the leu-enkephalin (300 μg/kg) was without effect if the drug injection was delayed 90 min. The results show that leu-enkephalin affects appetitive conditioning in much the same way as avoidance conditioning, a finding that suggests that leu-enkephalin may generally influence learning and memory.
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U2 - 10.1037/0735-7044.100.1.33
DO - 10.1037/0735-7044.100.1.33
M3 - Article
C2 - 3513799
AN - SCOPUS:0022628823
SN - 0735-7044
VL - 100
SP - 33
EP - 38
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
IS - 1
ER -