Leu-enkephalin Impairs Memory of an Appetitive Maze Response in Mice

David J Linden, Joe L. Martinez

Research output: Contribution to journalArticle

Abstract

Leu-enkephalin (300 μg/kg) impaired memory of a Y-maze response in mice when the animals were trained to obtain food in one arm of the maze. The dose-response function was U-shaped, with neither 100 nor 600 μg/kg having any effect. Des-Tyr-Leu-enkephalin, a nonopioid peptide, had no effect at doses equimolar to the leu-enkephalin. Finally, the leu-enkephalin (300 μg/kg) was without effect if the drug injection was delayed 90 min. The results show that leu-enkephalin affects appetitive conditioning in much the same way as avoidance conditioning, a finding that suggests that leu-enkephalin may generally influence learning and memory.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalBehavioral Neuroscience
Volume100
Issue number1
DOIs
StatePublished - Feb 1986
Externally publishedYes

Fingerprint

Leucine Enkephalin
Learning
Food
Peptides
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Leu-enkephalin Impairs Memory of an Appetitive Maze Response in Mice. / Linden, David J; Martinez, Joe L.

In: Behavioral Neuroscience, Vol. 100, No. 1, 02.1986, p. 33-38.

Research output: Contribution to journalArticle

@article{aa69c79398974527b2e4ee96fccb2e60,
title = "Leu-enkephalin Impairs Memory of an Appetitive Maze Response in Mice",
abstract = "Leu-enkephalin (300 μg/kg) impaired memory of a Y-maze response in mice when the animals were trained to obtain food in one arm of the maze. The dose-response function was U-shaped, with neither 100 nor 600 μg/kg having any effect. Des-Tyr-Leu-enkephalin, a nonopioid peptide, had no effect at doses equimolar to the leu-enkephalin. Finally, the leu-enkephalin (300 μg/kg) was without effect if the drug injection was delayed 90 min. The results show that leu-enkephalin affects appetitive conditioning in much the same way as avoidance conditioning, a finding that suggests that leu-enkephalin may generally influence learning and memory.",
author = "Linden, {David J} and Martinez, {Joe L.}",
year = "1986",
month = "2",
doi = "10.1037/0735-7044.100.1.33",
language = "English (US)",
volume = "100",
pages = "33--38",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "1",

}

TY - JOUR

T1 - Leu-enkephalin Impairs Memory of an Appetitive Maze Response in Mice

AU - Linden, David J

AU - Martinez, Joe L.

PY - 1986/2

Y1 - 1986/2

N2 - Leu-enkephalin (300 μg/kg) impaired memory of a Y-maze response in mice when the animals were trained to obtain food in one arm of the maze. The dose-response function was U-shaped, with neither 100 nor 600 μg/kg having any effect. Des-Tyr-Leu-enkephalin, a nonopioid peptide, had no effect at doses equimolar to the leu-enkephalin. Finally, the leu-enkephalin (300 μg/kg) was without effect if the drug injection was delayed 90 min. The results show that leu-enkephalin affects appetitive conditioning in much the same way as avoidance conditioning, a finding that suggests that leu-enkephalin may generally influence learning and memory.

AB - Leu-enkephalin (300 μg/kg) impaired memory of a Y-maze response in mice when the animals were trained to obtain food in one arm of the maze. The dose-response function was U-shaped, with neither 100 nor 600 μg/kg having any effect. Des-Tyr-Leu-enkephalin, a nonopioid peptide, had no effect at doses equimolar to the leu-enkephalin. Finally, the leu-enkephalin (300 μg/kg) was without effect if the drug injection was delayed 90 min. The results show that leu-enkephalin affects appetitive conditioning in much the same way as avoidance conditioning, a finding that suggests that leu-enkephalin may generally influence learning and memory.

UR - http://www.scopus.com/inward/record.url?scp=0022628823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022628823&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.100.1.33

DO - 10.1037/0735-7044.100.1.33

M3 - Article

C2 - 3513799

AN - SCOPUS:0022628823

VL - 100

SP - 33

EP - 38

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 1

ER -