Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus: Report of a very unusual combination

Amy Farkas, David Joyner, Ali G. Saad, Mark Anderson, Majid Khan

Research output: Contribution to journalArticle

Abstract

Dysembryoplastic neuroepithelial tumors (DNETs) are typically benign World Health Organization (WHO) grade I tumors of the cortical or deep gray matter with a favorable prognosis. We encountered a patient with DNET who has been evaluated and treated for West Nile encephalitis 7 months before presentation. Over the course of 2 years, the patient developed diffuse leptomeningeal carcinomatosis. As the disease burden increased, the patient eventually became quadriparetic. The patient elected for hospice care and expired shortly thereafter. Autopsy revealed DNET (WHO grade I) with extensive involvement of the cervical, thoracic, and lumbar spinal cord, bilateral cerebellar hemispheres, brainstem, the cortex of the right frontal and temporal lobes, and meningeal carcinomatosis of the brain and spinal cord. Mortality from DNET is rare, and as per our extensive literature search, there has been only 1 case reported of death attributed to seizures from this diagnosis. To the best of our knowledge, this is the only case of disseminated DNET with meningeal infiltration or carcinomatosis resulting in mortality.

Original languageEnglish (US)
Pages (from-to)555-558
Number of pages4
JournalRadiology Case Reports
Volume13
Issue number3
DOIs
Publication statusPublished - Jun 1 2018
Externally publishedYes

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Keywords

  • Dysembryoplastic neuroepithelial tumor
  • Leptomeningeal carcinomatosis
  • West Nile virus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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