Lessons to be learned from a complicated case of rhino-cerebral mucormycosis in a renal allograft recipient

Ruth Ladurner, Gerald Brandacher, Wolfgang Steurer, Stefan Schneeberger, Claudia Bösmüller, Martin Clemens Freund, Alfons Kreczy, Alfred Königsrainer, Raimund Margreiter

Research output: Contribution to journalArticle

Abstract

Fungal infections still represent a serious complication after organ transplantation. Early diagnosis and aggressive treatment are crucial. Because of the many diagnostic problems involved, we present a case of mucormycosis - primarily affecting the paranasal sinuses with later intracranial extension - in a highly immunized recipient of a third renal transplant. Although fungal infection was suspected from various imaging techniques, only the detection of typical fungal hyphae in the infected tissue was diagnostic. Neither the blood tests and cerebrospinal fluid examinations performed nor cultures from maxillary sinus fluid were of any diagnostic help. Surgical debridement from a transnasal as well as an intracranial approach and systemic amphotericin B together with the discontinuation of immunosuppression after removal of the rejected graft were able to save the patient. This case stresses the importance of early diagnosis that can only be made from tissue biopsies and allows appropriate timely treatment.

Original languageEnglish (US)
Pages (from-to)885-889
Number of pages5
JournalTransplant International
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Keywords

  • Fungal infection
  • Immunosuppression
  • Mucormycosis
  • Rhino-cerebral infection

ASJC Scopus subject areas

  • Transplantation

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    Ladurner, R., Brandacher, G., Steurer, W., Schneeberger, S., Bösmüller, C., Freund, M. C., Kreczy, A., Königsrainer, A., & Margreiter, R. (2003). Lessons to be learned from a complicated case of rhino-cerebral mucormycosis in a renal allograft recipient. Transplant International, 16(12), 885-889. https://doi.org/10.1007/s00147-003-0648-5