Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model

Q. Q. Quartey, R. J. Miller, B. L. Pinsker, U. J. Okoh, W. D. Shipman, B. A. George, C. C. Nwizu, L. A. Barnes, M. L. Kerns, J. A. Caffrey, O. Aliu, I. D. Brown, F. Succaria, J. P. Maynard, A. S. Herbert, S. Kang, L. S. Miller, G. A. Okoye, A. S. Byrd

Research output: Contribution to journalArticle

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalClinical and Experimental Dermatology
Volume45
Issue number2
DOIs
StatePublished - Mar 1 2020

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ASJC Scopus subject areas

  • Dermatology

Cite this

Quartey, Q. Q., Miller, R. J., Pinsker, B. L., Okoh, U. J., Shipman, W. D., George, B. A., Nwizu, C. C., Barnes, L. A., Kerns, M. L., Caffrey, J. A., Aliu, O., Brown, I. D., Succaria, F., Maynard, J. P., Herbert, A. S., Kang, S., Miller, L. S., Okoye, G. A., & Byrd, A. S. (2020). Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model. Clinical and Experimental Dermatology, 45(2), 202-206. https://doi.org/10.1111/ced.14054