Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model

Q. Q. Quartey, R. J. Miller, B. L. Pinsker, U. J. Okoh, W. D. Shipman, B. A. George, C. C. Nwizu, L. A. Barnes, M. L. Kerns, J. A. Caffrey, O. Aliu, I. D. Brown, F. Succaria, J. P. Maynard, A. S. Herbert, S. Kang, L. S. Miller, G. A. Okoye, A. S. Byrd

Research output: Contribution to journalArticle

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model.

Original languageEnglish (US)
JournalClinical and Experimental Dermatology
DOIs
StateAccepted/In press - Jan 1 2019

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Hidradenitis Suppurativa
Heterografts
Animal Models
Skin Diseases
Abscess
Cicatrix

ASJC Scopus subject areas

  • Dermatology

Cite this

Quartey, Q. Q., Miller, R. J., Pinsker, B. L., Okoh, U. J., Shipman, W. D., George, B. A., ... Byrd, A. S. (Accepted/In press). Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model. Clinical and Experimental Dermatology. https://doi.org/10.1111/ced.14054

Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model. / Quartey, Q. Q.; Miller, R. J.; Pinsker, B. L.; Okoh, U. J.; Shipman, W. D.; George, B. A.; Nwizu, C. C.; Barnes, L. A.; Kerns, M. L.; Caffrey, J. A.; Aliu, O.; Brown, I. D.; Succaria, F.; Maynard, J. P.; Herbert, A. S.; Kang, S.; Miller, L. S.; Okoye, G. A.; Byrd, A. S.

In: Clinical and Experimental Dermatology, 01.01.2019.

Research output: Contribution to journalArticle

Quartey, QQ, Miller, RJ, Pinsker, BL, Okoh, UJ, Shipman, WD, George, BA, Nwizu, CC, Barnes, LA, Kerns, ML, Caffrey, JA, Aliu, O, Brown, ID, Succaria, F, Maynard, JP, Herbert, AS, Kang, S, Miller, LS, Okoye, GA & Byrd, AS 2019, 'Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model', Clinical and Experimental Dermatology. https://doi.org/10.1111/ced.14054
Quartey, Q. Q. ; Miller, R. J. ; Pinsker, B. L. ; Okoh, U. J. ; Shipman, W. D. ; George, B. A. ; Nwizu, C. C. ; Barnes, L. A. ; Kerns, M. L. ; Caffrey, J. A. ; Aliu, O. ; Brown, I. D. ; Succaria, F. ; Maynard, J. P. ; Herbert, A. S. ; Kang, S. ; Miller, L. S. ; Okoye, G. A. ; Byrd, A. S. / Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model. In: Clinical and Experimental Dermatology. 2019.
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