Lessons learned from next-generation sequencing in head and neck cancer

Myriam Loyo; Ryan J. Li; Chetan Bettegowda; Curtis R. Pickering; Mitchell J. Frederick; Jeffrey N. Myers; Nishant Agrawal

doi:10.1002/hed.23100

Lessons learned from next-generation sequencing in head and neck cancer

Myriam Loyo, Ryan J. Li, Chetan Bettegowda, Curtis R. Pickering, Mitchell J. Frederick, Jeffrey N. Myers, Nishant Agrawal

School of Medicine

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53, NOTCH1, HRAS, PIK3CA, and CDKN2A. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed.

Original language	English (US)
Pages (from-to)	454-463
Number of pages	10
Journal	Head and Neck
Volume	35
Issue number	3
DOIs	https://doi.org/10.1002/hed.23100
State	Published - Mar 2013

Keywords

head and neck squamous cell carcinoma
mutations
next generation sequencing
oncogene
tumor suppressor gene

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23100

Cite this

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abstract = "Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53, NOTCH1, HRAS, PIK3CA, and CDKN2A. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed.",

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AU - Li, Ryan J.

AU - Bettegowda, Chetan

AU - Pickering, Curtis R.

AU - Frederick, Mitchell J.

AU - Myers, Jeffrey N.

AU - Agrawal, Nishant

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AB - Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next-generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1, a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53, NOTCH1, HRAS, PIK3CA, and CDKN2A. Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed.

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Lessons learned from next-generation sequencing in head and neck cancer

Abstract

Keywords

ASJC Scopus subject areas

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