Lessons from studies of antigen-specific T cell responses in multiple sclerosis

R. Martin, B. Bielekova, B. Gran, H. F. McFarland

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple Sclerosis (MS) is considered a T cell-mediated autoimmune disease of central nervous system myelin. Based on elegant experiments in an animal model of MS, experimental allergic encephalomyelitis (EAE), a number of myelin proteins and peptides derived from these can induce inflammatory demyelinating lesions. Recent studies with transgenic mice expressing human HLA-DR molecules and a myelin basic protein (MBP)-specific T cell receptor as well as data from a phase II clinical trial with an altered peptide ligand based on MBP peptide (83-99) provide convincing evidence that the pathogenetic concepts which largely stem from the above EAE studies are valid in MS, too.

Original languageEnglish (US)
Pages (from-to)361-373
Number of pages13
JournalJournal of Neural Transmission, Supplement
Issue number60
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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