TY - JOUR
T1 - Lessons from murine models of atopic dermatitis
AU - Zheng, Tao
AU - Zhu, Zhou
N1 - Funding Information:
This work was supported by NIH K08 grant AI055064 to Tao Zheng and by NIH R01 grant HL07-4-095 and the American Lung Association Research Grant to Zhou Zhu.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2005/7
Y1 - 2005/7
N2 - Atopic dermatitis (AD) is a complex disease that manifests immunologic abnormalities in the skin. The immunologic changes of AD are characterized by a T helper cell type 2 (Th2)-dominated immune response in its acute phase and a Th1/Th2 mixed immune response in its chronic phase. Although the clinical presentation and pathologic changes are initially in the skin, AD may be, in part, a systemic disorder. In fact, AD is often considered to be the initial manifestation of the "atopic march" that progresses from AD to allergic rhinitis and asthma. In the past several years, a number of murine models of AD have been developed or discovered, and studies on these models have contributed greatly to our understanding of the immunopathogenesis of this disease. This review is focused on these recent, illuminating advances in animal models of AD.
AB - Atopic dermatitis (AD) is a complex disease that manifests immunologic abnormalities in the skin. The immunologic changes of AD are characterized by a T helper cell type 2 (Th2)-dominated immune response in its acute phase and a Th1/Th2 mixed immune response in its chronic phase. Although the clinical presentation and pathologic changes are initially in the skin, AD may be, in part, a systemic disorder. In fact, AD is often considered to be the initial manifestation of the "atopic march" that progresses from AD to allergic rhinitis and asthma. In the past several years, a number of murine models of AD have been developed or discovered, and studies on these models have contributed greatly to our understanding of the immunopathogenesis of this disease. This review is focused on these recent, illuminating advances in animal models of AD.
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U2 - 10.1007/s11882-005-0069-x
DO - 10.1007/s11882-005-0069-x
M3 - Review article
C2 - 15967070
AN - SCOPUS:23844505898
SN - 1529-7322
VL - 5
SP - 291
EP - 297
JO - Current allergy and asthma reports
JF - Current allergy and asthma reports
IS - 4
ER -