Lessons for AIDS vaccine development from non-AIDS vaccines

M. L. Clements-Mann, C. D. Harro

Research output: Contribution to journalReview articlepeer-review

Abstract

Critical misconceptions about vaccine development have arisen in the context of acquired immunodeficiency syndrome (AIDS) vaccine research. These include: the goal of vaccination; the biological relevance and predictive value of animal models; the meaning of 'correlates of protective immunity'; the nature and duration of vaccine-induced immune responses; and the need for multiple, iterative field trials. In this article, lessons from the history of successful vaccine development relevant to these issues are discussed. Clarity about these central issues and adherence to a common vocabulary are important for the process of establishing an appropriate, milestone-driven process for developing safe, effective AIDS vaccines.

Original languageEnglish (US)
Pages (from-to)S-197-S-203
JournalAIDS research and human retroviruses
Volume14
Issue numberSUPPL. 3
StatePublished - Nov 20 1998

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Lessons for AIDS vaccine development from non-AIDS vaccines'. Together they form a unique fingerprint.

Cite this