TY - JOUR
T1 - Lessons and challenges for measles control from unexpected large outbreak, Malawi
AU - Minetti, Andrea
AU - Kagoli, Matthew
AU - Katsulukuta, Agnes
AU - Huerga, Helena
AU - Featherstone, Amber
AU - Chiotcha, Hazel
AU - Noel, Delphine
AU - Bopp, Cameron
AU - Sury, Laurent
AU - Fricke, Renzo
AU - Iscla, Marta
AU - Hurtado, Northan
AU - Ducomble, Tanya
AU - Nicholas, Sarala
AU - Kabuluzi, Storn
AU - Grais, Rebecca F.
AU - Luquero, Francisco J.
PY - 2013
Y1 - 2013
N2 - Despite high reported coverage for routine and supplementary immunization, in 2010 in Malawi, a large measles outbreak occurred that comprised 134,000 cases and 304 deaths. Although the highest attack rates were for young children (2.3%, 7.6%, and 4.5% for children 15 years of age were highly affected (1.0% and 0.4% for persons 15-19 and >19 years, respectively; 28% of all cases). A survey in 8 districts showed routine coverage of 95.0% for children 12-23 months; 57.9% for children 9-11 months; and 60.7% for children covered during the last supplementary immunization activities in 2008. Vaccine effectiveness was 83.9% for 1 dose and 90.5% for 2 doses. A continuous accumulation of susceptible persons during the past decade probably accounts for this outbreak. Countries en route to measles elimination, such as Malawi, should improve outbreak preparedness. Timeliness and the population chosen are crucial elements for reactive campaigns.
AB - Despite high reported coverage for routine and supplementary immunization, in 2010 in Malawi, a large measles outbreak occurred that comprised 134,000 cases and 304 deaths. Although the highest attack rates were for young children (2.3%, 7.6%, and 4.5% for children 15 years of age were highly affected (1.0% and 0.4% for persons 15-19 and >19 years, respectively; 28% of all cases). A survey in 8 districts showed routine coverage of 95.0% for children 12-23 months; 57.9% for children 9-11 months; and 60.7% for children covered during the last supplementary immunization activities in 2008. Vaccine effectiveness was 83.9% for 1 dose and 90.5% for 2 doses. A continuous accumulation of susceptible persons during the past decade probably accounts for this outbreak. Countries en route to measles elimination, such as Malawi, should improve outbreak preparedness. Timeliness and the population chosen are crucial elements for reactive campaigns.
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U2 - 10.3201/eid1902.120301
DO - 10.3201/eid1902.120301
M3 - Article
AN - SCOPUS:84930479319
SN - 1080-6040
VL - 19
SP - 202
EP - 209
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 2
ER -