Less death in the dying

Kornelia Polyak, Tsung Teh Wu, Stanley R. Hamilton, Kenneth W Kinzler, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

Diseases associated with aging are now the primary causes of death in developed countries. This is in part due to the long recognized exponential association of cancer with age and perhaps to a deterioration of the immune system with advanced age. Both prevention of tumorigenesis and immune function are critically dependent on apoptosis. In this study we examined apoptosis in mice of various age following gamma irradiation. We found a striking age-dependent decrease in radiation-induced apoptosis in splenic lymphocytes but not in colorectal epithelial cells. These observations may therefore provide a clue to the decline of immune function with age.

Original languageEnglish (US)
Pages (from-to)242-246
Number of pages5
JournalCell Death and Differentiation
Volume4
Issue number3
StatePublished - Apr 1997

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Apoptosis
Developed Countries
Cause of Death
Immune System
Carcinogenesis
Epithelial Cells
Lymphocytes
Radiation
Neoplasms

Keywords

  • Aging
  • Apoptosis
  • Immune system
  • Radiation

ASJC Scopus subject areas

  • Cell Biology

Cite this

Polyak, K., Wu, T. T., Hamilton, S. R., Kinzler, K. W., & Vogelstein, B. (1997). Less death in the dying. Cell Death and Differentiation, 4(3), 242-246.

Less death in the dying. / Polyak, Kornelia; Wu, Tsung Teh; Hamilton, Stanley R.; Kinzler, Kenneth W; Vogelstein, Bert.

In: Cell Death and Differentiation, Vol. 4, No. 3, 04.1997, p. 242-246.

Research output: Contribution to journalArticle

Polyak, K, Wu, TT, Hamilton, SR, Kinzler, KW & Vogelstein, B 1997, 'Less death in the dying', Cell Death and Differentiation, vol. 4, no. 3, pp. 242-246.
Polyak K, Wu TT, Hamilton SR, Kinzler KW, Vogelstein B. Less death in the dying. Cell Death and Differentiation. 1997 Apr;4(3):242-246.
Polyak, Kornelia ; Wu, Tsung Teh ; Hamilton, Stanley R. ; Kinzler, Kenneth W ; Vogelstein, Bert. / Less death in the dying. In: Cell Death and Differentiation. 1997 ; Vol. 4, No. 3. pp. 242-246.
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