Lesion quantification in dual-modality mammotomography

Heng Li, Yibin Zheng, Mitali J. More, Patricia J. Goodale, Mark B. Williams

Research output: Contribution to journalArticle

Abstract

This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalIEEE Transactions on Nuclear Science
Volume54
Issue number1
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

Fingerprint

Radioactivity
radioactivity
breast
lesions
image reconstruction
Image reconstruction
Imaging systems
artifacts
acquisition
sampling
Sampling
X rays
dosage
estimates
x rays

Keywords

  • Breast imaging
  • Dual modality imaging
  • Image reconstruction
  • SPECT
  • Tumor quantification

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Lesion quantification in dual-modality mammotomography. / Li, Heng; Zheng, Yibin; More, Mitali J.; Goodale, Patricia J.; Williams, Mark B.

In: IEEE Transactions on Nuclear Science, Vol. 54, No. 1, 01.02.2007, p. 107-115.

Research output: Contribution to journalArticle

Li, H, Zheng, Y, More, MJ, Goodale, PJ & Williams, MB 2007, 'Lesion quantification in dual-modality mammotomography', IEEE Transactions on Nuclear Science, vol. 54, no. 1, pp. 107-115. https://doi.org/10.1109/TNS.2006.884204
Li, Heng ; Zheng, Yibin ; More, Mitali J. ; Goodale, Patricia J. ; Williams, Mark B. / Lesion quantification in dual-modality mammotomography. In: IEEE Transactions on Nuclear Science. 2007 ; Vol. 54, No. 1. pp. 107-115.
@article{bd2768e819de4ae2aa668ab2ebacdc27,
title = "Lesion quantification in dual-modality mammotomography",
abstract = "This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10{\%} and quantification of radioactivity to an accuracy of 20{\%} are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.",
keywords = "Breast imaging, Dual modality imaging, Image reconstruction, SPECT, Tumor quantification",
author = "Heng Li and Yibin Zheng and More, {Mitali J.} and Goodale, {Patricia J.} and Williams, {Mark B.}",
year = "2007",
month = "2",
day = "1",
doi = "10.1109/TNS.2006.884204",
language = "English (US)",
volume = "54",
pages = "107--115",
journal = "IEEE Transactions on Nuclear Science",
issn = "0018-9499",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "1",

}

TY - JOUR

T1 - Lesion quantification in dual-modality mammotomography

AU - Li, Heng

AU - Zheng, Yibin

AU - More, Mitali J.

AU - Goodale, Patricia J.

AU - Williams, Mark B.

PY - 2007/2/1

Y1 - 2007/2/1

N2 - This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.

AB - This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.

KW - Breast imaging

KW - Dual modality imaging

KW - Image reconstruction

KW - SPECT

KW - Tumor quantification

UR - http://www.scopus.com/inward/record.url?scp=33847726986&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847726986&partnerID=8YFLogxK

U2 - 10.1109/TNS.2006.884204

DO - 10.1109/TNS.2006.884204

M3 - Article

AN - SCOPUS:33847726986

VL - 54

SP - 107

EP - 115

JO - IEEE Transactions on Nuclear Science

JF - IEEE Transactions on Nuclear Science

SN - 0018-9499

IS - 1

ER -