Lesion quantification in dual-modality mammotomography

Heng Li; Yibin Zheng; Mitali J. More; Patricia J. Goodale; Mark B. Williams

doi:10.1109/TNS.2006.884204

Lesion quantification in dual-modality mammotomography

Heng Li, Yibin Zheng, Mitali J. More, Patricia J. Goodale, Mark B. Williams

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.

Original language	English (US)
Pages (from-to)	107-115
Number of pages	9
Journal	IEEE Transactions on Nuclear Science
Volume	54
Issue number	1
DOIs	https://doi.org/10.1109/TNS.2006.884204
State	Published - Feb 2007
Externally published	Yes

Keywords

Breast imaging
Dual modality imaging
Image reconstruction
SPECT
Tumor quantification

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

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10.1109/TNS.2006.884204

Cite this

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title = "Lesion quantification in dual-modality mammotomography",

abstract = "This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.",

keywords = "Breast imaging, Dual modality imaging, Image reconstruction, SPECT, Tumor quantification",

author = "Heng Li and Yibin Zheng and More, {Mitali J.} and Goodale, {Patricia J.} and Williams, {Mark B.}",

note = "Funding Information: Manuscript received March 15, 2006; revised June 22, 2006. This work was supported in part by Grants from the National Institutes of Health (RO1 CA69452 and RO1 CA66232), the U.S. Army Breast Cancer Research Program (BC980469), and the Susan G. Komen Foundation (99-003050).",

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doi = "10.1109/TNS.2006.884204",

language = "English (US)",

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pages = "107--115",

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publisher = "Institute of Electrical and Electronics Engineers Inc.",

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AU - Li, Heng

AU - Zheng, Yibin

AU - More, Mitali J.

AU - Goodale, Patricia J.

AU - Williams, Mark B.

N1 - Funding Information: Manuscript received March 15, 2006; revised June 22, 2006. This work was supported in part by Grants from the National Institutes of Health (RO1 CA69452 and RO1 CA66232), the U.S. Army Breast Cancer Research Program (BC980469), and the Susan G. Komen Foundation (99-003050).

PY - 2007/2

Y1 - 2007/2

N2 - This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.

AB - This paper describes a novel x-ray/SPECT dual modality breast imaging system that provides 3D structural and functional information. While only a limited number of views on one side of the breast can be acquired due to mechanical and time constraints, we developed a technique to compensate for the limited angle artifact in reconstruction images and accurately estimate both the lesion size and radioactivity concentration. Various angular sampling strategies were evaluated using both simulated and experimental data. It was demonstrated that quantification of lesion size to an accuracy of 10% and quantification of radioactivity to an accuracy of 20% are feasible from limited-angle data acquired with clinically practical dosage and acquisition time.

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KW - Dual modality imaging

KW - Image reconstruction

KW - SPECT

KW - Tumor quantification

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Lesion quantification in dual-modality mammotomography

Abstract

Keywords

ASJC Scopus subject areas

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