Lesion location in depression post traumatic brain injury using magnetic resonance spectroscopy: Preliminary results from a pilot study

Vani Rao, Jennifer Spiro, Mahaveer Degoankar, Alena Horská, Paul B. Rosenberg, David M. Yousem, Peter B. Barker, D. Phil

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine the metabolic status of the brain in post traumatic brain injury(TBI) depression using proton magnetic resonance spectroscopy (MRS). Design: Case-control study including 5 TBI depressed subjects and 5 age matched non-TBI non-depressed controls. Methods: Metabolic status was assessed using proton MRS. Ratios of N-acetylaspartate (NAA), choline (Cho) and total creatine (Cr) were calculated in frontal cortex, basal ganglia and thalamus. Results: NAA/Cho or NAA/Cr ratios were significantly reduced in the TBI depressed group compared to controls in frontal cortex, basal ganglia and thalamus. Conclusion: Reduced levels of NAA in frontal regions, basal ganglia and thalamus in TBI depression suggest neuronal damage or dysfunction which may be a associated with the primary brain injury or with depressed mood.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalEuropean Journal of Psychiatry
Volume20
Issue number2
DOIs
StatePublished - 2006

Keywords

  • Depression
  • Magnetic Resonance Spectroscopy
  • Traumatic Brain Injury

ASJC Scopus subject areas

  • Psychiatry and Mental health

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