TY - JOUR
T1 - Leptospira seropositivity as a risk factor for Mesoamerican Nephropathy
AU - Riefkohl, Alejandro
AU - Ramírez-Rubio, Oriana
AU - Laws, Rebecca L.
AU - McClean, Michael D.
AU - Weiner, Daniel E.
AU - Kaufman, James S.
AU - Galloway, Renee L.
AU - Shadomy, Sean V.
AU - Guerra, Marta
AU - Amador, Juan José
AU - Sánchez, José Marcel
AU - López-Pilarte, Damaris
AU - Parikh, Chirag R.
AU - Leibler, Jessica H.
AU - Brooks, Daniel R.
N1 - Funding Information:
Funding for the research conducted was the result of a mediation process convened by the Compliance Advisor/ Ombudsman (CAO), the independent accountability mechanism for social and environmental issues of IFC/ MIGA of the World Bank Group, between Nicaragua Sugar Estates Limited (NSEL) and Asociación de Chichigalpa por la Vida (ASOCHIVIDA). The funds were provided by the CAO and the Comité Nacional de Productores de Azúcar (CNPA), of which NSEL is a member. The CAO managed all funds and maintained the contract to conduct the research, with the agreement of both parties involved in the mediation. Additional funding was also provided through internal funds from the Boston University School of Public Health. ORR was also funded by the Enrique Najera predoctoral grant awarded by the Spanish Society of Epidemiology and the Instituto de Salud Carlos III. RLL was also funded by a National Institutes of Health training grant [grant number T32 ES014562]; a STAR Fellowship Assistance agreement No. FP-91764901-0 awarded by the U.S. Environmental Protection Agency (EPA). The EPA does not endorse any products or commercial services mentioned in this publication. The views expressed in this publication are solely those of the authors and do not necessarily represent the official position of the affiliated institutions. Donors have not reviewed or influenced the content of this paper.
Funding Information:
Funding for the research conducted was the result of a mediation process convened by the Compliance Advisor/Ombudsman (CAO), the independent accountability mechanism for social and environmental issues of IFC/MIGA of the World Bank Group, between Nicaragua Sugar Estates Limited (NSEL) and Asociaci?n de Chichigalpa por la Vida (ASOCHIVIDA). The funds were provided by the CAO and the Comit? Nacional de Productores de Az?car (CNPA), of which NSEL is a member. The CAO managed all funds and maintained the contract to conduct the research, with the agreement of both parties involved in the mediation. Additional funding was also provided through internal funds from the Boston University School of Public Health. ORR was also funded by the Enrique Najera predoctoral grant awarded by the Spanish Society of Epidemiology and the Instituto de Salud Carlos III. RLL was also funded by a National Institutes of Health training grant [grant number T32 ES014562]; a STAR Fellowship Assistance agreement No. FP-91764901-0 awarded by the U.S. Environmental Protection Agency (EPA). The EPA does not endorse any products or commercial services mentioned in this publication. The views expressed in this publication are solely those of the authors and do not necessarily represent the official position of the affiliated institutions. Donors have not reviewed or influenced the content of this paper. We thank the workers for their participation in this study. We also thank the Nicaraguan Ministry of Health for contributions to the field investigation and laboratory support.
Funding Information:
Funding for additional studies has been provided by the CNPA and Los Azucareros Del Istmo Centroamericano (AICA) and was managed by the CDC Foundation. Dr. Parikh is listed as a co-inventor on a IL-18 patent granted to University of Colorado (no monetary value).
Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/1/2
Y1 - 2017/1/2
N2 - Background: Leptospirosis is postulated as a possible cause of Mesoamerican Nephropathy (MeN) in Central American workers. Objectives: Investigate job-specific Leptospira seroprevalence and its association with kidney disease biomarkers. Methods: In 282 sugarcane workers, 47 sugarcane applicants and 160 workers in other industries, we measured anti-leptospiral antibodies, serum creatinine, and urinary injury biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and N-acetyl-D-glucosaminidase (NAG). Results:Leptospira seroprevalence differed among job categories and was highest among sugarcane cutters (59%). Seropositive sugarcane workers had higher NGAL concentrations (relative mean: 1.28; 95% CI: 0.94–1.75) compared to those who were seronegative, with similar findings among field and non-field workers. Conclusions:Leptospira seroprevalence varied by job category. There was some indication that seropositivity was associated with elevated biomarker levels, but results were inconsistent. Additional studies may help establish whether Leptospira infection plays any role in MeN among Central American workers.
AB - Background: Leptospirosis is postulated as a possible cause of Mesoamerican Nephropathy (MeN) in Central American workers. Objectives: Investigate job-specific Leptospira seroprevalence and its association with kidney disease biomarkers. Methods: In 282 sugarcane workers, 47 sugarcane applicants and 160 workers in other industries, we measured anti-leptospiral antibodies, serum creatinine, and urinary injury biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and N-acetyl-D-glucosaminidase (NAG). Results:Leptospira seroprevalence differed among job categories and was highest among sugarcane cutters (59%). Seropositive sugarcane workers had higher NGAL concentrations (relative mean: 1.28; 95% CI: 0.94–1.75) compared to those who were seronegative, with similar findings among field and non-field workers. Conclusions:Leptospira seroprevalence varied by job category. There was some indication that seropositivity was associated with elevated biomarker levels, but results were inconsistent. Additional studies may help establish whether Leptospira infection plays any role in MeN among Central American workers.
KW - Chronic kidney disease (CKD)
KW - Chronic kidney disease of nontraditional etiology (CKDnt)
KW - Ieptospirosis
KW - Interleukin-18 (IL-18)
KW - Leptospira
KW - Mesoamerican Nephropathy (MeN)
KW - N-acetyl-D- glucosaminidase (NAG)
KW - Neutrophil gelatinase-associated lipocalin (NGAL)
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U2 - 10.1080/10773525.2016.1275462
DO - 10.1080/10773525.2016.1275462
M3 - Article
C2 - 28209095
AN - SCOPUS:85013127968
SN - 1077-3525
VL - 23
SP - 1
EP - 10
JO - International Journal of Occupational and Environmental Health
JF - International Journal of Occupational and Environmental Health
IS - 1
ER -