Leptin signaling and obesity: Cardiovascular consequences

Ronghua Yang, Lili A. Barouch

Research output: Contribution to journalReview article

Abstract

Leptin, among the best known hormone markers for obesity, exerts pleiotropic actions on multiple organ systems. In this review, we summarize major leptin signaling pathways, namely Janus-activated kinase/signal transducers and activators of transcription and mitogen-activated protein kinase, including possible mechanisms of leptin resistance in obesity. The effects of leptin on the cardiovascular system are discussed in detail, including its contributions to hypertension, atherosclerosis, depressed myocardial contractile function, fatty acid metabolism, hypertrophic remodeling, and reduction of ischemic/reperfusion injury. The overall goal is to summarize current understanding of how altered leptin signaling in obesity contributes to obesity-related cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)545-559
Number of pages15
JournalCirculation research
Volume101
Issue number6
DOIs
StatePublished - Sep 1 2007

Keywords

  • Cardiovascular disease
  • Leptin
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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