Leptin signaling

Rexford S. Ahima, Suzette Y. Osei

Research output: Contribution to journalArticlepeer-review


The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems.

Original languageEnglish (US)
Pages (from-to)223-241
Number of pages19
JournalPhysiology and Behavior
Issue number2
StatePublished - Apr 2004
Externally publishedYes


  • Feeding
  • Hypothalamus
  • Leptin
  • Neuropeptide
  • Obesity

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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