Leptin and its role in pregnancy and fetal development - An overview

M. L. Reitman, Sheng Bi, B. Marcus-Samuels, O. Gavrilova

Research output: Contribution to journalArticle

Abstract

Leptin is a hormone that is secreted by adipose cells in proportion to adipose mass, and therefore a low leptin level signifies depletion of energy stores. It has been proposed that leptin is one of the signals controlling sexual maturation. For example, humans and rodents lacking leptin fail to undergo complete puberty, while overexpression of leptin in mice causes early puberty. The placenta also produces leptin in human pregnancy, increasing the amount in the maternal circulation. The effects of the increased leptin levels during pregnancy are not clear. In contrast, the mouse placenta does not produce endocrinologically significant amounts of leptin. The mouse placenta does secrete a leptin-binding protein, the production of which correlates with a large increase in maternal leptin levels. The physiology of leptin during pregnancy and fetal development differs significantly between species, and is not well understood in any.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalBiochemical Society Transactions
Volume29
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Fetal Development
Leptin
Pregnancy
Placenta
Puberty
Mothers
Leptin Receptors
Sexual Maturation
Physiology
Rodentia
Hormones

Keywords

  • Energy homoeostasis
  • Paracrine effects
  • Placenta

ASJC Scopus subject areas

  • Biochemistry

Cite this

Leptin and its role in pregnancy and fetal development - An overview. / Reitman, M. L.; Bi, Sheng; Marcus-Samuels, B.; Gavrilova, O.

In: Biochemical Society Transactions, Vol. 29, No. 2, 2001, p. 68-72.

Research output: Contribution to journalArticle

Reitman, M. L. ; Bi, Sheng ; Marcus-Samuels, B. ; Gavrilova, O. / Leptin and its role in pregnancy and fetal development - An overview. In: Biochemical Society Transactions. 2001 ; Vol. 29, No. 2. pp. 68-72.
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