Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)

Seth Martin, Michael Blaha, Evan D. Muse, Atif N. Qasim, Muredach P. Reilly, Roger S Blumenthal, Khurram Nasir, Michael H. Criqui, Robyn L. McClelland, Jan M. Hughes-Austin, Matthew A. Allison

Research output: Contribution to journalArticle

Abstract

Objective: Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a modern, community-based, ethnically-diverse, and sex-balanced prospective cohort study of US adults free from cardiovascular disease. Serum leptin was measured in an ancillary study in 2002-2005. This analysis included 1905 MESA participants with baseline leptin and incident cardiovascular event data. Leptin levels were modeled as a log-transformed continuous variable and multivariable-adjusted Cox regression was performed for the primary outcome of hard cardiovascular disease, including coronary heart disease and stroke. Results: The median follow-up was 7.6 years (25th-75th 7.1-8.3) with 7051 and 6738 person-years of follow-up in women and men. A hard cardiovascular disease event occurred in 47 women and 63 men. The age- and ethnicity-adjusted hazard ratio estimates for a 1 standard deviation increase in ln(leptin) were 1.16 in women (95% CI 0.78-1.73, p=0.46) and 0.91 (95% CI 0.69-1.20, p=0.51) in men. Pooling sexes, and adjusting for sex in addition to age and ethnicity, estimates were 0.98 (95% CI 0.78-1.23, p=0.89). With additional adjustment for cardiovascular risk factors, the results remained nonsignificant: 0.87 (95% CI 0.68-1.11, p=0.26). Conclusion: In conclusion, in a modern, US prospective cohort study of multi-ethnic women and men of multi-ethnic backgrounds, leptin levels are not associated with incident cardiovascular events.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalAtherosclerosis
Volume239
Issue number1
DOIs
StatePublished - Mar 1 2015

Fingerprint

Leptin
Atherosclerosis
Cardiovascular Diseases
Cohort Studies
Serum
Prospective Studies
Coronary Disease
Stroke
Incidence

Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Heart failure
  • Leptin
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Leptin and incident cardiovascular disease : The Multi-Ethnic Study of Atherosclerosis (MESA). / Martin, Seth; Blaha, Michael; Muse, Evan D.; Qasim, Atif N.; Reilly, Muredach P.; Blumenthal, Roger S; Nasir, Khurram; Criqui, Michael H.; McClelland, Robyn L.; Hughes-Austin, Jan M.; Allison, Matthew A.

In: Atherosclerosis, Vol. 239, No. 1, 01.03.2015, p. 67-72.

Research output: Contribution to journalArticle

Martin, S, Blaha, M, Muse, ED, Qasim, AN, Reilly, MP, Blumenthal, RS, Nasir, K, Criqui, MH, McClelland, RL, Hughes-Austin, JM & Allison, MA 2015, 'Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)', Atherosclerosis, vol. 239, no. 1, pp. 67-72. https://doi.org/10.1016/j.atherosclerosis.2014.12.033
Martin, Seth ; Blaha, Michael ; Muse, Evan D. ; Qasim, Atif N. ; Reilly, Muredach P. ; Blumenthal, Roger S ; Nasir, Khurram ; Criqui, Michael H. ; McClelland, Robyn L. ; Hughes-Austin, Jan M. ; Allison, Matthew A. / Leptin and incident cardiovascular disease : The Multi-Ethnic Study of Atherosclerosis (MESA). In: Atherosclerosis. 2015 ; Vol. 239, No. 1. pp. 67-72.
@article{0637d231e31a466192ede39be377fd36,
title = "Leptin and incident cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)",
abstract = "Objective: Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a modern, community-based, ethnically-diverse, and sex-balanced prospective cohort study of US adults free from cardiovascular disease. Serum leptin was measured in an ancillary study in 2002-2005. This analysis included 1905 MESA participants with baseline leptin and incident cardiovascular event data. Leptin levels were modeled as a log-transformed continuous variable and multivariable-adjusted Cox regression was performed for the primary outcome of hard cardiovascular disease, including coronary heart disease and stroke. Results: The median follow-up was 7.6 years (25th-75th 7.1-8.3) with 7051 and 6738 person-years of follow-up in women and men. A hard cardiovascular disease event occurred in 47 women and 63 men. The age- and ethnicity-adjusted hazard ratio estimates for a 1 standard deviation increase in ln(leptin) were 1.16 in women (95{\%} CI 0.78-1.73, p=0.46) and 0.91 (95{\%} CI 0.69-1.20, p=0.51) in men. Pooling sexes, and adjusting for sex in addition to age and ethnicity, estimates were 0.98 (95{\%} CI 0.78-1.23, p=0.89). With additional adjustment for cardiovascular risk factors, the results remained nonsignificant: 0.87 (95{\%} CI 0.68-1.11, p=0.26). Conclusion: In conclusion, in a modern, US prospective cohort study of multi-ethnic women and men of multi-ethnic backgrounds, leptin levels are not associated with incident cardiovascular events.",
keywords = "Atherosclerosis, Cardiovascular disease, Heart failure, Leptin, Obesity",
author = "Seth Martin and Michael Blaha and Muse, {Evan D.} and Qasim, {Atif N.} and Reilly, {Muredach P.} and Blumenthal, {Roger S} and Khurram Nasir and Criqui, {Michael H.} and McClelland, {Robyn L.} and Hughes-Austin, {Jan M.} and Allison, {Matthew A.}",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.atherosclerosis.2014.12.033",
language = "English (US)",
volume = "239",
pages = "67--72",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Leptin and incident cardiovascular disease

T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)

AU - Martin, Seth

AU - Blaha, Michael

AU - Muse, Evan D.

AU - Qasim, Atif N.

AU - Reilly, Muredach P.

AU - Blumenthal, Roger S

AU - Nasir, Khurram

AU - Criqui, Michael H.

AU - McClelland, Robyn L.

AU - Hughes-Austin, Jan M.

AU - Allison, Matthew A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Objective: Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a modern, community-based, ethnically-diverse, and sex-balanced prospective cohort study of US adults free from cardiovascular disease. Serum leptin was measured in an ancillary study in 2002-2005. This analysis included 1905 MESA participants with baseline leptin and incident cardiovascular event data. Leptin levels were modeled as a log-transformed continuous variable and multivariable-adjusted Cox regression was performed for the primary outcome of hard cardiovascular disease, including coronary heart disease and stroke. Results: The median follow-up was 7.6 years (25th-75th 7.1-8.3) with 7051 and 6738 person-years of follow-up in women and men. A hard cardiovascular disease event occurred in 47 women and 63 men. The age- and ethnicity-adjusted hazard ratio estimates for a 1 standard deviation increase in ln(leptin) were 1.16 in women (95% CI 0.78-1.73, p=0.46) and 0.91 (95% CI 0.69-1.20, p=0.51) in men. Pooling sexes, and adjusting for sex in addition to age and ethnicity, estimates were 0.98 (95% CI 0.78-1.23, p=0.89). With additional adjustment for cardiovascular risk factors, the results remained nonsignificant: 0.87 (95% CI 0.68-1.11, p=0.26). Conclusion: In conclusion, in a modern, US prospective cohort study of multi-ethnic women and men of multi-ethnic backgrounds, leptin levels are not associated with incident cardiovascular events.

AB - Objective: Higher serum leptin levels have been associated with a modestly higher incidence of cardiovascular disease in studies involving mostly Caucasian men. We aimed to assess the hypothesis that higher baseline levels of serum leptin are associated with higher risk of future cardiovascular disease in a diverse cohort. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) is a modern, community-based, ethnically-diverse, and sex-balanced prospective cohort study of US adults free from cardiovascular disease. Serum leptin was measured in an ancillary study in 2002-2005. This analysis included 1905 MESA participants with baseline leptin and incident cardiovascular event data. Leptin levels were modeled as a log-transformed continuous variable and multivariable-adjusted Cox regression was performed for the primary outcome of hard cardiovascular disease, including coronary heart disease and stroke. Results: The median follow-up was 7.6 years (25th-75th 7.1-8.3) with 7051 and 6738 person-years of follow-up in women and men. A hard cardiovascular disease event occurred in 47 women and 63 men. The age- and ethnicity-adjusted hazard ratio estimates for a 1 standard deviation increase in ln(leptin) were 1.16 in women (95% CI 0.78-1.73, p=0.46) and 0.91 (95% CI 0.69-1.20, p=0.51) in men. Pooling sexes, and adjusting for sex in addition to age and ethnicity, estimates were 0.98 (95% CI 0.78-1.23, p=0.89). With additional adjustment for cardiovascular risk factors, the results remained nonsignificant: 0.87 (95% CI 0.68-1.11, p=0.26). Conclusion: In conclusion, in a modern, US prospective cohort study of multi-ethnic women and men of multi-ethnic backgrounds, leptin levels are not associated with incident cardiovascular events.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Heart failure

KW - Leptin

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84920732376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920732376&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2014.12.033

DO - 10.1016/j.atherosclerosis.2014.12.033

M3 - Article

C2 - 25574859

AN - SCOPUS:84920732376

VL - 239

SP - 67

EP - 72

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -