Leptin

Rexford S Ahima, J. S. Flier

Research output: Contribution to journalReview article

Abstract

The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in the regulation of feeding and energy balance. Plasma leptin levels correlate with fat stores and respond to changes in energy balance. It was initially proposed that leptin serves a primary role as an anti-obesity hormone, but this role is commonly thwarted by leptin resistance. Leptin also serves as a mediator of the adaptation to fasting, and this role may be the primary function for which the molecule evolved. There is increasing evidence that leptin has systemic effects apart from those related to energy homeostasis, including regulation of neuroendocrine and immune function and a role in development.

Original languageEnglish (US)
Pages (from-to)413-437
Number of pages25
JournalAnnual Review of Physiology
Volume62
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Leptin
Hormones
Fasting
Homeostasis
Obesity
Fats
Brain

Keywords

  • Adipose tissue
  • Feeding
  • Metabolism
  • Neuroendocrine

ASJC Scopus subject areas

  • Physiology

Cite this

Leptin. / Ahima, Rexford S; Flier, J. S.

In: Annual Review of Physiology, Vol. 62, 2000, p. 413-437.

Research output: Contribution to journalReview article

Ahima, Rexford S ; Flier, J. S. / Leptin. In: Annual Review of Physiology. 2000 ; Vol. 62. pp. 413-437.
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