Leprosy associated with HLA‐DR2 and DQwl in the population of northern Thailand

Victoria Schauf; Sharon Ryan; David Scollard; Olga Jonasson; Arthur Brown; Kenrad Nelson; Treavor Smith; Vicharn Vithayasai

doi:10.1111/j.1399-0039.1985.tb00966.x

Leprosy associated with HLA‐DR2 and DQwl in the population of northern Thailand

Victoria Schauf, Sharon Ryan, David Scollard, Olga Jonasson, Arthur Brown, Kenrad Nelson, Treavor Smith, Vicharn Vithayasai

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A study of the frequency of HLA‐DR2 and DQwl was performed in leprosy patients and controls in northern Thailand. HLA‐DR2 was found in 100% (17/17) of patients with sporadic tuberculoid leprosy and in over 90% (30/32) of all tuberculoid leprosy patients, as compared to 62% (20/32) of controls (p = .02). These strong associations had relative risks of 21.4 for sporadic and 7.4 for all tuberculoid leprosy, and etiologic fractions of 1.0 and 0.84, respectively. There was also a statistically significant and strong association between tuberculoid leprosy and DQwl. These data add to the growing body of evidence that products of HLA class II determinants or closely linked genes may play a role in determining the clinical manifestations of M. leprae infection.

Original language	English (US)
Pages (from-to)	243-247
Number of pages	5
Journal	Tissue Antigens
Volume	26
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-0039.1985.tb00966.x
State	Published - Oct 1985
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Biochemistry
Genetics

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10.1111/j.1399-0039.1985.tb00966.x

Cite this

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title = "Leprosy associated with HLA‐DR2 and DQwl in the population of northern Thailand",

abstract = "A study of the frequency of HLA‐DR2 and DQwl was performed in leprosy patients and controls in northern Thailand. HLA‐DR2 was found in 100% (17/17) of patients with sporadic tuberculoid leprosy and in over 90% (30/32) of all tuberculoid leprosy patients, as compared to 62% (20/32) of controls (p = .02). These strong associations had relative risks of 21.4 for sporadic and 7.4 for all tuberculoid leprosy, and etiologic fractions of 1.0 and 0.84, respectively. There was also a statistically significant and strong association between tuberculoid leprosy and DQwl. These data add to the growing body of evidence that products of HLA class II determinants or closely linked genes may play a role in determining the clinical manifestations of M. leprae infection.",

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AU - Schauf, Victoria

AU - Ryan, Sharon

AU - Scollard, David

AU - Jonasson, Olga

AU - Brown, Arthur

AU - Nelson, Kenrad

AU - Smith, Treavor

AU - Vithayasai, Vicharn

PY - 1985/10

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N2 - A study of the frequency of HLA‐DR2 and DQwl was performed in leprosy patients and controls in northern Thailand. HLA‐DR2 was found in 100% (17/17) of patients with sporadic tuberculoid leprosy and in over 90% (30/32) of all tuberculoid leprosy patients, as compared to 62% (20/32) of controls (p = .02). These strong associations had relative risks of 21.4 for sporadic and 7.4 for all tuberculoid leprosy, and etiologic fractions of 1.0 and 0.84, respectively. There was also a statistically significant and strong association between tuberculoid leprosy and DQwl. These data add to the growing body of evidence that products of HLA class II determinants or closely linked genes may play a role in determining the clinical manifestations of M. leprae infection.

AB - A study of the frequency of HLA‐DR2 and DQwl was performed in leprosy patients and controls in northern Thailand. HLA‐DR2 was found in 100% (17/17) of patients with sporadic tuberculoid leprosy and in over 90% (30/32) of all tuberculoid leprosy patients, as compared to 62% (20/32) of controls (p = .02). These strong associations had relative risks of 21.4 for sporadic and 7.4 for all tuberculoid leprosy, and etiologic fractions of 1.0 and 0.84, respectively. There was also a statistically significant and strong association between tuberculoid leprosy and DQwl. These data add to the growing body of evidence that products of HLA class II determinants or closely linked genes may play a role in determining the clinical manifestations of M. leprae infection.

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Leprosy associated with HLA‐DR2 and DQwl in the population of northern Thailand

Abstract

ASJC Scopus subject areas

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