Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand

V. Schauf, S. Ryan, D. Scollard, O. Jonasson, A. Brown, Kenrad Edwin Nelson, T. Smith, V. Vithayasai

Research output: Contribution to journalArticle

Abstract

A study of the frequency of HLA-DR2 and DQw1 was performed in leprosy patients and controls in northern Thailand. HLA-DR2 was found in 100% (17/17) of patients with sporadic tuberculoid leprosy and in over 90% (30/32) of all tuberculoid leprosy patients, as compared to 62% (20/32) of controls (p = .02). These strong associations had relative risks of 21.4 for sporadic and 7.4 for all tuberculoid leprosy, and etiologic fractions of 1.0 and 0.84, respectively. There was also a statistically significant and strong association between tuberculoid leprosy and DQw1. These data add to the growing body of evidence that products of HLA class II determinants or closely linked genes may play a role in determining the clinical manifestations of M. leprae infection.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalTissue Antigens
Volume26
Issue number4
StatePublished - 1985
Externally publishedYes

Fingerprint

HLA-DR2 Antigen
Tuberculoid Leprosy
Leprosy
Thailand
Population
HLA-DQ1 antigen
Infection
Genes

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Schauf, V., Ryan, S., Scollard, D., Jonasson, O., Brown, A., Nelson, K. E., ... Vithayasai, V. (1985). Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. Tissue Antigens, 26(4), 243-247.

Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. / Schauf, V.; Ryan, S.; Scollard, D.; Jonasson, O.; Brown, A.; Nelson, Kenrad Edwin; Smith, T.; Vithayasai, V.

In: Tissue Antigens, Vol. 26, No. 4, 1985, p. 243-247.

Research output: Contribution to journalArticle

Schauf, V, Ryan, S, Scollard, D, Jonasson, O, Brown, A, Nelson, KE, Smith, T & Vithayasai, V 1985, 'Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand', Tissue Antigens, vol. 26, no. 4, pp. 243-247.
Schauf V, Ryan S, Scollard D, Jonasson O, Brown A, Nelson KE et al. Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. Tissue Antigens. 1985;26(4):243-247.
Schauf, V. ; Ryan, S. ; Scollard, D. ; Jonasson, O. ; Brown, A. ; Nelson, Kenrad Edwin ; Smith, T. ; Vithayasai, V. / Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. In: Tissue Antigens. 1985 ; Vol. 26, No. 4. pp. 243-247.
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AU - Brown, A.

AU - Nelson, Kenrad Edwin

AU - Smith, T.

AU - Vithayasai, V.

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