Lentiviral Vif: Viral hijacker of the ubiquitin-proteasome system

Elana S. Ehrlich, Xiao Fang Yu

Research output: Contribution to journalReview article

Abstract

Since the beginning of time, microorganisms have been devising ways to bypass detection and destruction by our immune system. Therefore, it is no surprise that along with the identification of the cellular antiviral protein APOBEC3G (A3G) has come the recognition of the viral solution to this assault. Here, we review the research that led up to the identification of A3G and the mechanism that the human immunodeficiency virus protein Vif developed to evade A3G's antiviral activities.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalInternational journal of hematology
Volume83
Issue number3
DOIs
StatePublished - Apr 1 2006

Keywords

  • APOBEC3
  • Cytidine deaminase
  • HIV
  • Vif

ASJC Scopus subject areas

  • Hematology

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