Lennox-Gastaut syndrome symptomatic to hypothalamic hamartoma

Evolution and long-term outcome following surgery

Sandipan Pati, Aman Deep, Matthew M. Troester, Eric H Kossoff, Yu Tze Ng

Research output: Contribution to journalArticle

Abstract

Background: Lennox-Gastaut syndrome is a catastrophic childhood cryptogenic or symptomatic epilepsy. Hypothalamic hamartomas cause refractory epilepsy often consistent with Lennox-Gastaut syndrome. Methods: Children with Lennox-Gastaut syndrome were defined by a triad of multiple generalized seizure types, slow spike-and-wave on EEG, and mental retardation. Results: Twenty-one of 159 hypothalamic hamartoma patients (14%) met the diagnostic criteria of Lennox-Gastaut syndrome. The median age of patients at epilepsy onset was 0.9 years (range, birth to 9 years). Six of the 21 patients (28%) had preceding infantile spasms. All patients underwent different surgical approaches, including endoscopic, transcallosal, orbitozygomatic resections, and radiosurgery treatment. Five of the 21 (24%) were seizure free with an additional 9 (42%) having at least >90% seizure reduction. Only 1 patient was not effectively treated (

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalPediatric Neurology
Volume49
Issue number1
DOIs
StatePublished - Jul 2013

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Epilepsy
Seizures
Infantile Spasms
Radiosurgery
Intellectual Disability
Electroencephalography
Lennox Gastaut Syndrome
Hypothalamic hamartomas
Parturition
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Lennox-Gastaut syndrome symptomatic to hypothalamic hamartoma : Evolution and long-term outcome following surgery. / Pati, Sandipan; Deep, Aman; Troester, Matthew M.; Kossoff, Eric H; Ng, Yu Tze.

In: Pediatric Neurology, Vol. 49, No. 1, 07.2013, p. 25-30.

Research output: Contribution to journalArticle

Pati, Sandipan ; Deep, Aman ; Troester, Matthew M. ; Kossoff, Eric H ; Ng, Yu Tze. / Lennox-Gastaut syndrome symptomatic to hypothalamic hamartoma : Evolution and long-term outcome following surgery. In: Pediatric Neurology. 2013 ; Vol. 49, No. 1. pp. 25-30.
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