Leishmanization: Use of an old method for evaluation of candidate vaccines against leishmaniasis

Ali Khamesipour, Yahya Dowlati, Ali Asilian, Reza Hashemi-Fesharki, Amir Javadi, Sassan Noazin, Farrokh Modabber

Research output: Contribution to journalArticlepeer-review

Abstract

To establish the safety and reproducibility of live challenge with Leishmania major, a single frozen stabilate was used in two open, single-arm leishmanization (LZ) trials. A total of 42 inoculations in 28 male adult volunteers were followed until complete healing. Lesions induced by LZ are as diverse as natural infection, but much milder. Total protection was seen in 100% (11/11) of recovered volunteers. LZ used as live challenge to test vaccine candidates reduces the required sample size, is cost effective for surrogate markers studies and will induce protection in the participants who are not protected by candidate vaccines.

Original languageEnglish (US)
Pages (from-to)3642-3648
Number of pages7
JournalVaccine
Volume23
Issue number28
DOIs
StatePublished - May 25 2005
Externally publishedYes

Keywords

  • Iran
  • Leishmania
  • Leishmanization
  • Live challenge
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Leishmanization: Use of an old method for evaluation of candidate vaccines against leishmaniasis'. Together they form a unique fingerprint.

Cite this