Legionnaires' disease in human immunodeficiency virus-infected patients: Eight cases and review

Stephen P. Blatt, Matthew J. Dolan, Craig Hendrix, Gregory P. Melcher

Research output: Contribution to journalArticle

Abstract

Despite being a well-known pathogen for immunocompromised patients, Legionella pneumophila has infrequently been described in persons with infection due to human immunodeficiency virus (HIV). Since 1986, we have identified eight cases of legionella pneumonia among seven HIV-infected persons enrolled in the HIV Natural History Study of the U.S. Air Force. The median CD4+ T cell count for these patients was 83/mm3; 50% of the cases occurred in persons for whom AIDS was previously diagnosed, and five of the cases were nosocomial. Six of the patients had coexistent pulmonary infections. None of the cases occurred among persons receiving prophylactic therapy with trimethoprim-sulfamethoxazole. Therapeutically, all patients appeared to respond well to standard antilegionella therapy or high doses of trimethoprim-sulfamethoxazole. Overall, these seven patients represent 1.7% of the patients with late-stage HIV infection (Walter Reed stage 5 or 6) in this cohort. L. pneumophila, although remaining an uncommon pathogen for HIV- infected patients, may produce serious disease in this population. HIV- infected persons should be considered at risk for legionnaires' disease, particularly in institutions where potable water supplies have become contaminated.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalClinical Infectious Diseases
Volume18
Issue number2
StatePublished - Feb 1994
Externally publishedYes

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Legionnaires' Disease
HIV
Legionella pneumophila
Sulfamethoxazole Drug Combination Trimethoprim
Legionella
Water Supply
Immunocompromised Host
Virus Diseases
CD4 Lymphocyte Count
Infection
Natural History
Drinking Water
Pneumonia
Acquired Immunodeficiency Syndrome
Air
T-Lymphocytes
Lung
Therapeutics
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Legionnaires' disease in human immunodeficiency virus-infected patients : Eight cases and review. / Blatt, Stephen P.; Dolan, Matthew J.; Hendrix, Craig; Melcher, Gregory P.

In: Clinical Infectious Diseases, Vol. 18, No. 2, 02.1994, p. 227-232.

Research output: Contribution to journalArticle

Blatt, Stephen P. ; Dolan, Matthew J. ; Hendrix, Craig ; Melcher, Gregory P. / Legionnaires' disease in human immunodeficiency virus-infected patients : Eight cases and review. In: Clinical Infectious Diseases. 1994 ; Vol. 18, No. 2. pp. 227-232.
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