@article{ac7193133ca84bd6b179acd5f1817e8c,
title = "Legacy of a 10-year multidomain lifestyle intervention on the cognitive trajectories of individuals with overweight/obesity and type 2 diabetes mellitus",
abstract = "Introduction: Weight loss and increased physical activity interventions are commonly recommended for individuals with type 2 diabetes (T2D) and overweight or obesity. We examined the impact of randomization to an intensive lifestyle intervention (ILI) on trajectories of cognitive function over 10 years in a cohort of participants in a randomized clinical trial who had T2D and overweight/obesity at baseline. Methods: Participants aged 45-76 years were enrolled in 2001-2004 and were randomized to the ILI or a diabetes support and education (DSE) condition. Cognitive function was assessed in 3,938 participants at up to 4 time points 8-18 years after randomization. General linear mixed effects models examined cognitive trajectories over time. Subgroup analyses focused on sex, individuals with baseline body mass index >30, those carrying the APOE ϵ4 allele, and those with a baseline history of cardiovascular disease (CVD). Results: Overall, there were no differences in the rate of cognitive decline by intervention arm. Subgroup analyses showed that participants who had a baseline history of CVD and were randomized to the ILI arm of the study performed significantly worse on the Stroop Color Word Test than those in the DSE arm. Discussion/Conclusions: The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.",
keywords = "Clinical trial, Cognitive decline, Executive function, Obesity, Overweight, Type 2 diabetes",
author = "Hayden, {Kathleen M.} and Neiberg, {Rebecca H.} and Evans, {Joni K.} and Luchsinger, {Jos{\'e} A.} and Owen Carmichael and Dutton, {Gareth R.} and Johnson, {Karen C.} and Kahn, {Steven E.} and Rapp, {Stephen R.} and Sevil Yasar and Espeland, {Mark A.}",
note = "Funding Information: The Action for Health in Diabetes is supported through the following cooperative agreements from the National Institutes of Health: DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. The Look AHEAD Brain MRI ancillary study was supported by the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services: DK092237-01 and DK092237-02S2. The Look AHEAD Movement and Memory ancillary study was supported by the National Institute on Aging, National Institutes of Health, Department of Health and Human Services, R01AG03308701. The Look AHEAD Mind ancillary study was funded by AG058571. The following federal agencies have contributed support: National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of Nursing Research; National Center on Minority Health and Health Disparities; Office of Research on Women{\textquoteright}s Health; the Centers for Disease Control and Prevention; the National Institute on Aging; and the Department of Veterans Affairs. This research was supported in part by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. The Indian Health Service (I.H.S.) provided personnel, medical oversight, and use of facilities. The opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the I.H.S. or other funding sources. Additional support was received from the University of Pittsburgh General Clinical Research Center (GCRC) (M01RR000056), the Clinical Translational Research Center (CTRC) funded by the Clinical & Translational Science Award (UL1 RR 024153) and NIH grant (DK 046204); Frederic C. Bartter General Clinical Research Center (M01RR01346); and the Wake Forest Alzheimer{\textquoteright}s Disease Core Center (P30AG049638-01A1). The following organizations have committed to make major contributions to Look AHEAD: FedEx Corporation; Health Management Resources; LifeScan, Inc., a Johnson & Johnson Company; OPTIFAST{\textregistered} of Nestle HealthCare Nutrition, Inc.; Hoffmann-La Roche Inc.; Abbott Nutrition; and Slim-Fast Brand of Unilever North America. Publisher Copyright: {\textcopyright} 2021 ",
year = "2021",
month = oct,
day = "1",
doi = "10.1159/000517160",
language = "English (US)",
volume = "50",
pages = "237--249",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "3",
}