Left ventricular wall thickness in patients with hypertrophic cardiomyopathy: a comparison between cardiac magnetic resonance imaging and echocardiography

Celia Corona Villalobos, Lars L. Sorensen, Iraklis Pozios, Linda Chi Hang Chu, John Eng, Maria Roselle Abraham, Theodore P. Abraham, Ihab R Kamel, Stefan Zimmerman

Research output: Contribution to journalArticle

Abstract

We assessed whether cardiac MRI (CMR) and echocardiography (echo) have significant differences measuring left ventricular (LV) wall thickness (WT) in hypertrophic cardiomyopathy (HCM) as performed in the clinical routine. Retrospectively identified, clinically diagnosed HCM patients with interventricular-septal (IVS) pattern hypertrophy who underwent CMR and echo within the same day were included. Left Ventricular WT was measured by CMR in two planes and compared to both echo and contrast echo (cecho). 72 subjects, mean age 50.7 ± 16.2 years, 68 % males. Interventricular septal WT by echo and CMR planes showed good to excellent correlation. However, measurements of the postero-lateral wall showed poor correlation. Bland–Altman plots showed greater maximal IVS WT by echo compared to CMR measurement [SAX = 1.7 mm (−5.8, 9.3); LVOT = 1.1 mm (−5.6, 7.8)]. Differences were smaller between cecho and CMR [SAX = 0.8 mm (−9.2, 10.8); LVOT = −0.2 mm (−10.0, 9.6)]. Severity of WT by quartiles showed greater differences between echo and SAX CMR WT compared to cecho. Echocardiography typically measures greater WT than CMR, with the largest differences in moderate to severe hypertrophy. Contrast echocardiography more closely approximates CMR measurements of WT. These findings have potential clinical implications for risk stratification of subjects with HCM.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalInternational Journal of Cardiovascular Imaging
DOIs
StateAccepted/In press - Feb 19 2016

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Hypertrophic Cardiomyopathy
Echocardiography
Magnetic Resonance Imaging
Hypertrophy

Keywords

  • Cardiac magnetic resonance imaging
  • Echocardiography
  • Hypertrophic cardiomyopathy
  • Inter-study variability
  • Wall thickness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Left ventricular wall thickness in patients with hypertrophic cardiomyopathy: a comparison between cardiac magnetic resonance imaging and echocardiography",
abstract = "We assessed whether cardiac MRI (CMR) and echocardiography (echo) have significant differences measuring left ventricular (LV) wall thickness (WT) in hypertrophic cardiomyopathy (HCM) as performed in the clinical routine. Retrospectively identified, clinically diagnosed HCM patients with interventricular-septal (IVS) pattern hypertrophy who underwent CMR and echo within the same day were included. Left Ventricular WT was measured by CMR in two planes and compared to both echo and contrast echo (cecho). 72 subjects, mean age 50.7 ± 16.2 years, 68 {\%} males. Interventricular septal WT by echo and CMR planes showed good to excellent correlation. However, measurements of the postero-lateral wall showed poor correlation. Bland–Altman plots showed greater maximal IVS WT by echo compared to CMR measurement [SAX = 1.7 mm (−5.8, 9.3); LVOT = 1.1 mm (−5.6, 7.8)]. Differences were smaller between cecho and CMR [SAX = 0.8 mm (−9.2, 10.8); LVOT = −0.2 mm (−10.0, 9.6)]. Severity of WT by quartiles showed greater differences between echo and SAX CMR WT compared to cecho. Echocardiography typically measures greater WT than CMR, with the largest differences in moderate to severe hypertrophy. Contrast echocardiography more closely approximates CMR measurements of WT. These findings have potential clinical implications for risk stratification of subjects with HCM.",
keywords = "Cardiac magnetic resonance imaging, Echocardiography, Hypertrophic cardiomyopathy, Inter-study variability, Wall thickness",
author = "{Corona Villalobos}, Celia and Sorensen, {Lars L.} and Iraklis Pozios and Chu, {Linda Chi Hang} and John Eng and Abraham, {Maria Roselle} and Abraham, {Theodore P.} and Kamel, {Ihab R} and Stefan Zimmerman",
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doi = "10.1007/s10554-016-0858-4",
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T2 - a comparison between cardiac magnetic resonance imaging and echocardiography

AU - Corona Villalobos, Celia

AU - Sorensen, Lars L.

AU - Pozios, Iraklis

AU - Chu, Linda Chi Hang

AU - Eng, John

AU - Abraham, Maria Roselle

AU - Abraham, Theodore P.

AU - Kamel, Ihab R

AU - Zimmerman, Stefan

PY - 2016/2/19

Y1 - 2016/2/19

N2 - We assessed whether cardiac MRI (CMR) and echocardiography (echo) have significant differences measuring left ventricular (LV) wall thickness (WT) in hypertrophic cardiomyopathy (HCM) as performed in the clinical routine. Retrospectively identified, clinically diagnosed HCM patients with interventricular-septal (IVS) pattern hypertrophy who underwent CMR and echo within the same day were included. Left Ventricular WT was measured by CMR in two planes and compared to both echo and contrast echo (cecho). 72 subjects, mean age 50.7 ± 16.2 years, 68 % males. Interventricular septal WT by echo and CMR planes showed good to excellent correlation. However, measurements of the postero-lateral wall showed poor correlation. Bland–Altman plots showed greater maximal IVS WT by echo compared to CMR measurement [SAX = 1.7 mm (−5.8, 9.3); LVOT = 1.1 mm (−5.6, 7.8)]. Differences were smaller between cecho and CMR [SAX = 0.8 mm (−9.2, 10.8); LVOT = −0.2 mm (−10.0, 9.6)]. Severity of WT by quartiles showed greater differences between echo and SAX CMR WT compared to cecho. Echocardiography typically measures greater WT than CMR, with the largest differences in moderate to severe hypertrophy. Contrast echocardiography more closely approximates CMR measurements of WT. These findings have potential clinical implications for risk stratification of subjects with HCM.

AB - We assessed whether cardiac MRI (CMR) and echocardiography (echo) have significant differences measuring left ventricular (LV) wall thickness (WT) in hypertrophic cardiomyopathy (HCM) as performed in the clinical routine. Retrospectively identified, clinically diagnosed HCM patients with interventricular-septal (IVS) pattern hypertrophy who underwent CMR and echo within the same day were included. Left Ventricular WT was measured by CMR in two planes and compared to both echo and contrast echo (cecho). 72 subjects, mean age 50.7 ± 16.2 years, 68 % males. Interventricular septal WT by echo and CMR planes showed good to excellent correlation. However, measurements of the postero-lateral wall showed poor correlation. Bland–Altman plots showed greater maximal IVS WT by echo compared to CMR measurement [SAX = 1.7 mm (−5.8, 9.3); LVOT = 1.1 mm (−5.6, 7.8)]. Differences were smaller between cecho and CMR [SAX = 0.8 mm (−9.2, 10.8); LVOT = −0.2 mm (−10.0, 9.6)]. Severity of WT by quartiles showed greater differences between echo and SAX CMR WT compared to cecho. Echocardiography typically measures greater WT than CMR, with the largest differences in moderate to severe hypertrophy. Contrast echocardiography more closely approximates CMR measurements of WT. These findings have potential clinical implications for risk stratification of subjects with HCM.

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