Left ventricular shape variation in asymptomatic populations: The multi-ethnic study of atherosclerosis

Pau Medrano-Gracia, Brett R. Cowan, Bharath Ambale Venkatesh, David A. Bluemke, John Eng, John Paul Finn, Carissa G. Fonseca, Joao Lima, Avan Suinesiaputra, Alistair A. Young

Research output: Contribution to journalArticle

Abstract

Background: Although left ventricular cardiac geometric indices such as size and sphericity characterize adverse remodeling and have prognostic value in symptomatic patients, little is known of shape distributions in subclinical populations. We sought to quantify shape variation across a large number of asymptomatic volunteers, and examine differences among sub-cohorts. Methods. An atlas was constructed comprising 1,991 cardiovascular magnetic resonance (CMR) cases contributed from the Multi-Ethnic Study of Atherosclerosis baseline examination. A mathematical model describing regional wall motion and shape was used to establish a coordinate map registered to the cardiac anatomy. The model was automatically customized to left ventricular contours and anatomical landmarks, corrected for breath-hold mis-registration between image slices. Mathematical techniques were used to characterize global shape distributions, after removal of translations, rotations, and scale due to height. Differences were quantified among ethnicity, sex, smoking, hypertension and diabetes sub-cohorts. Results: The atlas construction process yielded accurate representations of global shape (errors between manual and automatic surface points in 244 validation cases were less than the image pixel size). After correction for height, the dominant shape component was associated with heart size, explaining 32% of the total shape variance at end-diastole and 29% at end-systole. After size, the second dominant shape component was sphericity at end-diastole (13%), and concentricity at end-systole (10%). The resulting shape components distinguished differences due to ethnicity and risk factors with greater statistical power than traditional mass and volume indices. Conclusions: We have quantified the dominant components of global shape variation in the adult asymptomatic population. The data and results are available at cardiacatlas.org. Shape distributions were principally explained by size, sphericity and concentricity, which are known correlates of adverse outcomes. Atlas-based global shape analysis provides a powerful method for quantifying left ventricular shape differences in asymptomatic populations. Trial registration. ClinicalTrials.gov.

Original languageEnglish (US)
Article number56
JournalJournal of Cardiovascular Magnetic Resonance
Volume16
Issue number1
DOIs
StatePublished - Jul 30 2014

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Atlases
Atherosclerosis
Diastole
Systole
Population
Volunteers
Anatomy
Theoretical Models
Magnetic Resonance Spectroscopy
Smoking
Hypertension

Keywords

  • Atlas
  • Cardiovascular magnetic resonance
  • Principal component analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice
  • Medicine(all)

Cite this

Left ventricular shape variation in asymptomatic populations : The multi-ethnic study of atherosclerosis. / Medrano-Gracia, Pau; Cowan, Brett R.; Ambale Venkatesh, Bharath; Bluemke, David A.; Eng, John; Finn, John Paul; Fonseca, Carissa G.; Lima, Joao; Suinesiaputra, Avan; Young, Alistair A.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 16, No. 1, 56, 30.07.2014.

Research output: Contribution to journalArticle

Medrano-Gracia, Pau ; Cowan, Brett R. ; Ambale Venkatesh, Bharath ; Bluemke, David A. ; Eng, John ; Finn, John Paul ; Fonseca, Carissa G. ; Lima, Joao ; Suinesiaputra, Avan ; Young, Alistair A. / Left ventricular shape variation in asymptomatic populations : The multi-ethnic study of atherosclerosis. In: Journal of Cardiovascular Magnetic Resonance. 2014 ; Vol. 16, No. 1.
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AU - Bluemke, David A.

AU - Eng, John

AU - Finn, John Paul

AU - Fonseca, Carissa G.

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