TY - GEN
T1 - Left-ventricular shape analysis for predicting sudden cardiac death risk
AU - Vadakkumpadan, Fijoy
AU - Trayanova, Natalia
AU - Younes, Laurent
AU - Wu, Katherine C.
PY - 2012
Y1 - 2012
N2 - Implantation of cardioverter defibrillators is the most widely used primary preventive care for sudden cardiac death (SCD). Current clinical practice of using a left-ventricular ejection fraction threshold as the sole criterion for defibrillator insertion results in many unnecessary implantations. To address the need for alternative criteria, we seek three-dimensional shape metrics of the left ventricle derived from clinical cardiac magnetic resonance images that can predict SCD risk. The present study is a proof-of-concept, where we have combined image-processing and computational anatomy techniques to develop a processing pipeline to statistically compare localized left ventricular shape metrics between patient groups. We tested the methodology with data from a small cohort of patients, classified into two groups based on SCD risk. The results demonstrate that our approach is able to locate systematic wall thickness differences between the two groups.
AB - Implantation of cardioverter defibrillators is the most widely used primary preventive care for sudden cardiac death (SCD). Current clinical practice of using a left-ventricular ejection fraction threshold as the sole criterion for defibrillator insertion results in many unnecessary implantations. To address the need for alternative criteria, we seek three-dimensional shape metrics of the left ventricle derived from clinical cardiac magnetic resonance images that can predict SCD risk. The present study is a proof-of-concept, where we have combined image-processing and computational anatomy techniques to develop a processing pipeline to statistically compare localized left ventricular shape metrics between patient groups. We tested the methodology with data from a small cohort of patients, classified into two groups based on SCD risk. The results demonstrate that our approach is able to locate systematic wall thickness differences between the two groups.
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U2 - 10.1109/EMBC.2012.6346860
DO - 10.1109/EMBC.2012.6346860
M3 - Conference contribution
C2 - 23366821
AN - SCOPUS:84880960760
SN - 9781424441198
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4067
EP - 4070
BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
T2 - 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
Y2 - 28 August 2012 through 1 September 2012
ER -