Left-ventricular shape analysis for predicting sudden cardiac death risk

Fijoy Vadakkumpadan, Natalia Trayanova, Laurent Younes, Katherine C. Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Implantation of cardioverter defibrillators is the most widely used primary preventive care for sudden cardiac death (SCD). Current clinical practice of using a left-ventricular ejection fraction threshold as the sole criterion for defibrillator insertion results in many unnecessary implantations. To address the need for alternative criteria, we seek three-dimensional shape metrics of the left ventricle derived from clinical cardiac magnetic resonance images that can predict SCD risk. The present study is a proof-of-concept, where we have combined image-processing and computational anatomy techniques to develop a processing pipeline to statistically compare localized left ventricular shape metrics between patient groups. We tested the methodology with data from a small cohort of patients, classified into two groups based on SCD risk. The results demonstrate that our approach is able to locate systematic wall thickness differences between the two groups.

Original languageEnglish (US)
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages4067-4070
Number of pages4
DOIs
StatePublished - 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Vadakkumpadan, F., Trayanova, N., Younes, L., & Wu, K. C. (2012). Left-ventricular shape analysis for predicting sudden cardiac death risk. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012 (pp. 4067-4070). [6346860] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6346860