Left ventricular long-axis function: Reference values of the mitral annular plane systolic excursion in 558 healthy children and calculation of z-score values

Martin Koestenberger, Bert Nagel, William Ravekes, Alexander Avian, Bernd Heinzl, Peter Fritsch, Andrea Fandl, Thomas Rehak, Andreas Gamillscheg

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Longitudinal myocardial function has gained more interest in the last years. The mitral annular plane systolic excursion (MAPSE) is an echocardiographic measurement to assess left ventricular (LV) long-axis function in adults. The aim of this study was to evaluate MAPSE values in a healthy pediatric population and to propose reference values. Methods: A prospective study was conducted in a group of 558 healthy children and adolescents (age day 1 to 18 years) (body surface area [BSA] 0.18-2.21 m2). We determined the effects of age and BSA on MAPSE values and a possible correlation of MAPSE values with LV ejection fraction values. Results: The MAPSE ranged from a mean of 0.57 cm (z-score ± 2: 0.38-0.76 cm) in neonates to 1.63 cm (z-score ± 2: 1.31-1.95 cm) in 18-year-old adolescents. The MAPSE values showed a positive correlation with age (r = 0.87, P < .001) and BSA (r = 0.89, P < .001) with a nonlinear course. There was no significant difference in MAPSE values between females or males. A positive correlation was found between MAPSE values and LV ejection fraction values (r = 0.28, P < .001). Conclusions: Z-scores of MAPSE values were calculated, and percentile charts were established to serve as reference data in patients with congenital heart disease or heart failure in the future.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalAmerican heart journal
Volume164
Issue number1
DOIs
StatePublished - Jul 1 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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