Left ventricular hypertrophy and remodeling and risk of cognitive impairment and dementia

MESA (Multi-Ethnic Study of Atherosclerosis)

Kasra Moazzami, Mohammad Reza Ostovaneh, Bharath Ambale Venkatesh, Mohammadali Habibi, Kihei Yoneyama, Colin Wu, Kiang Liu, Isabel Pimenta, Annette Fitzpatrick, Steven Shea, Robyn L. McClelland, Susan Heckbert, Rebecca F Gottesman, David A. Bluemke, Timothy M. Hughes, Joao Lima

Research output: Contribution to journalArticle

Abstract

Limited information exists on the longitudinal association between the left ventricular (LV) structure and function and future cognitive impairment and dementia in a large population without clinically recognized cardiovascular disease at baseline. The aim of the present study was to investigate the association between cardiac structure and function and risk of dementia and cognitive impairment in the MESA (Multi-Ethnic Study of Atherosclerosis) cohort. Measures of LV structure and function were determined using magnetic resonance imaging at baseline in 4999 participants free of clinically diagnosed cardiovascular disease and dementia. Probable incident clinical dementia was ascertained from hospitalization discharge records. Cognitive function was evaluated using tests addressing global cognitive function, processing speed, and memory. Associations of measures of LV structure and function with the incidence of clinically diagnosed dementia and cognitive performance were evaluated using Cox proportional hazard regression models adjusted for demographics, cardiovascular risk factors, and cardiovascular events. During a median follow-up of 12 years, 130 probable incident dementia cases were documented. Higher LV mass index (hazard ratio, 1.01; 95% confidence interval, 1.00-1.02) and LV mass-to-volume ratio (hazard ratio, 2.37; 95% confidence interval, 1.25-4.43) were independently associated with incident dementia and impaired cognitive function. Measures of LV function were not associated with risk of dementia or cognitive impairment. In conclusion, in a multiethnic cohort of participants without clinically detected cardiovascular disease and dementia at baseline, LV hypertrophy and concentric remodeling were independently associated with incident dementia and cognitive impairment.

Original languageEnglish (US)
Pages (from-to)429-436
Number of pages8
JournalHypertension
Volume71
Issue number3
DOIs
StatePublished - Jan 1 2018

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Ventricular Remodeling
Left Ventricular Hypertrophy
Dementia
Atherosclerosis
Left Ventricular Function
Cognition
Cardiovascular Diseases
Cognitive Dysfunction
Confidence Intervals
Proportional Hazards Models
Hospitalization
Cohort Studies
Magnetic Resonance Imaging
Demography

Keywords

  • Cognitive dysfunction
  • Dementia
  • Follow-up studies
  • Heart ventricles
  • Risk factors

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Left ventricular hypertrophy and remodeling and risk of cognitive impairment and dementia : MESA (Multi-Ethnic Study of Atherosclerosis). / Moazzami, Kasra; Ostovaneh, Mohammad Reza; Ambale Venkatesh, Bharath; Habibi, Mohammadali; Yoneyama, Kihei; Wu, Colin; Liu, Kiang; Pimenta, Isabel; Fitzpatrick, Annette; Shea, Steven; McClelland, Robyn L.; Heckbert, Susan; Gottesman, Rebecca F; Bluemke, David A.; Hughes, Timothy M.; Lima, Joao.

In: Hypertension, Vol. 71, No. 3, 01.01.2018, p. 429-436.

Research output: Contribution to journalArticle

Moazzami, K, Ostovaneh, MR, Ambale Venkatesh, B, Habibi, M, Yoneyama, K, Wu, C, Liu, K, Pimenta, I, Fitzpatrick, A, Shea, S, McClelland, RL, Heckbert, S, Gottesman, RF, Bluemke, DA, Hughes, TM & Lima, J 2018, 'Left ventricular hypertrophy and remodeling and risk of cognitive impairment and dementia: MESA (Multi-Ethnic Study of Atherosclerosis)', Hypertension, vol. 71, no. 3, pp. 429-436. https://doi.org/10.1161/HYPERTENSIONAHA.117.10289
Moazzami, Kasra ; Ostovaneh, Mohammad Reza ; Ambale Venkatesh, Bharath ; Habibi, Mohammadali ; Yoneyama, Kihei ; Wu, Colin ; Liu, Kiang ; Pimenta, Isabel ; Fitzpatrick, Annette ; Shea, Steven ; McClelland, Robyn L. ; Heckbert, Susan ; Gottesman, Rebecca F ; Bluemke, David A. ; Hughes, Timothy M. ; Lima, Joao. / Left ventricular hypertrophy and remodeling and risk of cognitive impairment and dementia : MESA (Multi-Ethnic Study of Atherosclerosis). In: Hypertension. 2018 ; Vol. 71, No. 3. pp. 429-436.
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AU - Yoneyama, Kihei

AU - Wu, Colin

AU - Liu, Kiang

AU - Pimenta, Isabel

AU - Fitzpatrick, Annette

AU - Shea, Steven

AU - McClelland, Robyn L.

AU - Heckbert, Susan

AU - Gottesman, Rebecca F

AU - Bluemke, David A.

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AU - Lima, Joao

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N2 - Limited information exists on the longitudinal association between the left ventricular (LV) structure and function and future cognitive impairment and dementia in a large population without clinically recognized cardiovascular disease at baseline. The aim of the present study was to investigate the association between cardiac structure and function and risk of dementia and cognitive impairment in the MESA (Multi-Ethnic Study of Atherosclerosis) cohort. Measures of LV structure and function were determined using magnetic resonance imaging at baseline in 4999 participants free of clinically diagnosed cardiovascular disease and dementia. Probable incident clinical dementia was ascertained from hospitalization discharge records. Cognitive function was evaluated using tests addressing global cognitive function, processing speed, and memory. Associations of measures of LV structure and function with the incidence of clinically diagnosed dementia and cognitive performance were evaluated using Cox proportional hazard regression models adjusted for demographics, cardiovascular risk factors, and cardiovascular events. During a median follow-up of 12 years, 130 probable incident dementia cases were documented. Higher LV mass index (hazard ratio, 1.01; 95% confidence interval, 1.00-1.02) and LV mass-to-volume ratio (hazard ratio, 2.37; 95% confidence interval, 1.25-4.43) were independently associated with incident dementia and impaired cognitive function. Measures of LV function were not associated with risk of dementia or cognitive impairment. In conclusion, in a multiethnic cohort of participants without clinically detected cardiovascular disease and dementia at baseline, LV hypertrophy and concentric remodeling were independently associated with incident dementia and cognitive impairment.

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