Left ventricular global function index by magnetic resonance imaging - A novel marker for assessment of cardiac performance for the prediction of cardiovascular events: The multi-ethnic study of atherosclerosis

Nathan Mewton, Anders Opdahl, Eui Young Choi, Andre L C Almeida, Nadine Kawel, Colin O. Wu, Gregory L. Burke, Songtao Liu, Kiang Liu, David A. Bluemke, Joao Lima

Research output: Contribution to journalArticle

Abstract

Left ventricular (LV) function is generally assessed independent of structural remodeling and vice versa. The purpose of this study was to evaluate a novel LV global function index (LVGFI) that integrates LV structure with global function and to assess its predictive value for cardiovascular (CV) events throughout adult life in a multiethnic population of men and women without history of CV diseases at baseline. A total of 5004 participants in the Multi-Ethnic Study of Atherosclerosis underwent a cardiac magnetic resonance study and were followed up for a median of 7.2 years. The LVGFI by cardiac magnetic resonance was defined by the ratio of stroke volume divided by LV total volume defined as the sum of mean LV cavity and myocardial volumes. Cox proportional hazard models were constructed to predict the end points of heart failure, hard CV events, and a combined end point of all CV events after adjustment for established risk factors, calcium score, and biomarkers. A total of 579 (11.6%) CV events were observed during the follow-up period. In adjusted models, the end points of heart failure, hard CV events, and all events were all significantly associated with LVGFI (heart failure, hazard ratio=0.64, P

Original languageEnglish (US)
Pages (from-to)770-778
Number of pages9
JournalHypertension
Volume61
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Left Ventricular Function
Atherosclerosis
Heart Failure
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Proportional Hazards Models
Stroke Volume
Cardiovascular Diseases
Biomarkers
Calcium
Population

Keywords

  • ejection fraction
  • heart failure
  • left ventricle
  • LV global function index
  • LV mass

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Left ventricular global function index by magnetic resonance imaging - A novel marker for assessment of cardiac performance for the prediction of cardiovascular events : The multi-ethnic study of atherosclerosis. / Mewton, Nathan; Opdahl, Anders; Choi, Eui Young; Almeida, Andre L C; Kawel, Nadine; Wu, Colin O.; Burke, Gregory L.; Liu, Songtao; Liu, Kiang; Bluemke, David A.; Lima, Joao.

In: Hypertension, Vol. 61, No. 4, 04.2013, p. 770-778.

Research output: Contribution to journalArticle

Mewton, Nathan ; Opdahl, Anders ; Choi, Eui Young ; Almeida, Andre L C ; Kawel, Nadine ; Wu, Colin O. ; Burke, Gregory L. ; Liu, Songtao ; Liu, Kiang ; Bluemke, David A. ; Lima, Joao. / Left ventricular global function index by magnetic resonance imaging - A novel marker for assessment of cardiac performance for the prediction of cardiovascular events : The multi-ethnic study of atherosclerosis. In: Hypertension. 2013 ; Vol. 61, No. 4. pp. 770-778.
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