Left atrial structure and functional quantitation using cardiovascular magnetic resonance and multimodality tissue tracking: Validation and reproducibility assessment

Mytra Zareian, Luisa Ciuffo, Mohammadali Habibi, Anders Opdahl, Elzbieta H. Chamera, Colin O. Wu, David A. Bluemke, João A.C. Lima, Bharath Ambale Venkatesh

Research output: Contribution to journalArticle

Abstract

Background: Left atrium (LA) strain, volume and function are important markers of cardiovascular disease and myocardial impairment. We aimed to assess the accuracy of LA biplane volume and function measured by Multimodality Tissue Tracking (MTT). Also we assessed the inter-study reproducibility for cardiovascular magnetic resonance (CMR) derived LA volume and function parameters. Methods: Thirty subjects (mean age: 71.3 ± 8.7, 87 % male) including twenty subjects with cardiovascular events and ten healthy subjects, with CMR were evaluated in the Multi-Ethnic Study of Atherosclerosis (MESA). LA volumes were computed by the modified biplane method from 2- and 4-chamber projections and the Simpson's method from short-axis slices using both methods - manual and semi-automated delineation using MTT. LA total, active and passive ejection fractions were calculated. Pearson's correlation and Bland-Altman analysis were used to compare the measurements. In a second sample of 25 subjects (age: 65.7 ± 7.1, 72 % males) inter study, intra and inter reader reliability analysis was performed. The intra-class correlation coefficient (ICC) was evaluated. Results: Left atrial MTT structural and functional parameters were not different from manual delineation, yet image analysis was only half as time consuming on average with MTT. Maximal volume MTT was not different between the Simpson's and Biplane methods, functional parameters, however were different. MTT allowed us to measure multiple LA parameters with good-excellent (ICC; 0.88- 0.98, p < 0.001) intra-and inter reader reproducibility and fair-good (ICC; 0.44-0.82, p < 0.05-0.001) inter study reproducibility. Conclusions: MTT derived LA biplane volume and function is accurate and reproducible and is suited for use in longitudinal studies.

Original languageEnglish (US)
Article number52
JournalJournal of Cardiovascular Magnetic Resonance
Volume17
Issue number1
DOIs
StatePublished - Jul 1 2015

Keywords

  • Cardiovascular magnetic resonance
  • Left atrial function
  • Left atrial strain
  • Reproducibility
  • Tissue tracking

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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