Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation

Research output: Research - peer-reviewArticle

Abstract

Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long-term anticoagulation. Multiple implantable devices have surfaced in the last few years, with some promising prospects. The main purpose of this review is to highlight the indications and use of these devices for left atrial appendage occlusion.

LanguageEnglish (US)
JournalClinical Cardiology
DOIs
StateAccepted/In press - 2017

Fingerprint

Atrial Appendage
Atrial Fibrillation
Stroke
Equipment and Supplies
Thromboembolism
Cardiac Arrhythmias
Thrombosis
Hemorrhage
Morbidity
Mortality

Keywords

  • Atrial Fibrillation
  • Left Atrial Appendage Occlusion
  • Stroke Prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation",
abstract = "Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long-term anticoagulation. Multiple implantable devices have surfaced in the last few years, with some promising prospects. The main purpose of this review is to highlight the indications and use of these devices for left atrial appendage occlusion.",
keywords = "Atrial Fibrillation, Left Atrial Appendage Occlusion, Stroke Prevention",
author = "Bajwa, {Rizma Jalees} and Lara Kovell and Resar, {Jon R.} and Armin Arbab-Zadeh and Kaushik Mandal and Hugh Calkins and Berger, {Ronald D.}",
year = "2017",
doi = "10.1002/clc.22764",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",

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T1 - Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation

AU - Bajwa,Rizma Jalees

AU - Kovell,Lara

AU - Resar,Jon R.

AU - Arbab-Zadeh,Armin

AU - Mandal,Kaushik

AU - Calkins,Hugh

AU - Berger,Ronald D.

PY - 2017

Y1 - 2017

N2 - Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long-term anticoagulation. Multiple implantable devices have surfaced in the last few years, with some promising prospects. The main purpose of this review is to highlight the indications and use of these devices for left atrial appendage occlusion.

AB - Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long-term anticoagulation. Multiple implantable devices have surfaced in the last few years, with some promising prospects. The main purpose of this review is to highlight the indications and use of these devices for left atrial appendage occlusion.

KW - Atrial Fibrillation

KW - Left Atrial Appendage Occlusion

KW - Stroke Prevention

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