Leflunomide: Is there a place for its use in transplantation?

Matthew J. Koch, Daniel C. Brennan

Research output: Contribution to journalReview articlepeer-review

Abstract

Leflunomide has several properties that make it an excellent candidate for use in transplantation, but concerns about the prolonged half-life and potential for hepatotoxicity temper the enthusiasm. As it will likely be several years before similar, shorter acting agents are available, continued study is warranted to discern the appropriate use in human transplantation of this currently available agent.

Original languageEnglish (US)
Pages (from-to)317-322
Number of pages6
JournalCurrent opinion in organ transplantation
Volume8
Issue number4
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • Dosing
  • Kinetics
  • Leflunomide
  • Malononitrilamide
  • Transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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