Learning induces long-term potentiation in the hippocampus

Jonathan R. Whitlock, Arnold J. Heynen, Marshall G. Shuler, Mark F. Bear

Research output: Contribution to journalArticle

Abstract

Years of intensive investigation have yielded a sophisticated understanding of long-term potentiation (LTP) induced in hippocampal area CA1 by high-frequency stimulation (HFS). These efforts have been motivated by the belief that similar synaptic modifications occur during memory formation, but it has never been shown that learning actually induces LTP in CA1. We found that one-trial inhibitory avoidance learning in rats produced the same changes in hippocampal glutamate receptors as induction of LTP with HFS and caused a spatially restricted increase in the amplitude of evoked synaptic transmission in CA1 in vivo. Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1.

Original languageEnglish (US)
Pages (from-to)1093-1097
Number of pages5
JournalScience
Volume313
Issue number5790
DOIs
StatePublished - Aug 25 2006

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    Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006). Learning induces long-term potentiation in the hippocampus. Science, 313(5790), 1093-1097. https://doi.org/10.1126/science.1128134