TY - GEN
T1 - Learning high-dimensional image statistics for abnormality detection on medical images
AU - Erus, Guray
AU - Zacharaki, Evangelia I.
AU - Bryan, Nick
AU - Davatzikos, Christos
PY - 2010
Y1 - 2010
N2 - We present a general methodology that aims to learn multi-variate statistics of high dimensional images, in order to capture the inter-individual variability of imaging data from a limited number of training images. The statistical learning procedure is used for identifying abnormalities as deviations from the normal variation. In most practical applications, learning an accurate statistical model of the observed data is a very challenging task due to the very high dimensionality of the images, and the limited number of available training samples. We attempt to overcome this problem by capturing the statistics of a large number of lower dimensional subspaces, which can be estimated more reliably. The subspaces are derived in a multi-scale fashion, and capture image characteristics ranging from fine and localized to coarser and relatively more global. The main premise is that an imaging pattern that is consistent with the statistics of a large number of subspaces, each reflecting a marginal probability density function (pdf), is likely to be consistent with the overall pdf, which hasn't been explicitly estimated. Abnormalities in a new image are identified as significant deviations from the normal variation captured by the learned subspace models, and are determined via iterative projections on these subspaces.
AB - We present a general methodology that aims to learn multi-variate statistics of high dimensional images, in order to capture the inter-individual variability of imaging data from a limited number of training images. The statistical learning procedure is used for identifying abnormalities as deviations from the normal variation. In most practical applications, learning an accurate statistical model of the observed data is a very challenging task due to the very high dimensionality of the images, and the limited number of available training samples. We attempt to overcome this problem by capturing the statistics of a large number of lower dimensional subspaces, which can be estimated more reliably. The subspaces are derived in a multi-scale fashion, and capture image characteristics ranging from fine and localized to coarser and relatively more global. The main premise is that an imaging pattern that is consistent with the statistics of a large number of subspaces, each reflecting a marginal probability density function (pdf), is likely to be consistent with the overall pdf, which hasn't been explicitly estimated. Abnormalities in a new image are identified as significant deviations from the normal variation captured by the learned subspace models, and are determined via iterative projections on these subspaces.
UR - http://www.scopus.com/inward/record.url?scp=77956533027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956533027&partnerID=8YFLogxK
U2 - 10.1109/CVPRW.2010.5543141
DO - 10.1109/CVPRW.2010.5543141
M3 - Conference contribution
AN - SCOPUS:77956533027
SN - 9781424470297
T3 - 2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition - Workshops, CVPRW 2010
SP - 139
EP - 145
BT - 2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition - Workshops, CVPRW 2010
T2 - 2010 IEEE Computer Society Conference on Computer Vision and Pattern Recognition - Workshops, CVPRW 2010
Y2 - 13 June 2010 through 18 June 2010
ER -