Learned control of ventricular rate in patients with atrial fibrillation

E. R. Bleecker, B. T. Engel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Six patients with chronic atrial fibrillation (AF) and rheumatic heart disease on stable digitalis regimens were trained to slow and to speed ventricular rate (VR). Two subjects were more consistent in their ability to slow VR; two subjects were more consistent in their ability to speed VR; and the remaining two subjects were able to slow and to speed VR reliably. All subjects were able to control VR differentially during sequential slowing and speeding phases of experimental training sessions. Analyses of R R interval histograms revealed that all subjects significantly changed the statistical frequency distributions of their R R intervals. During VR slowing one subject generated a junctional escape rhythm. Another subject produced frequent premature ventricular contractions during speeding of VR under effective β adrenergic blockade with propranolol. This control of VR in AF is neurally mediated at the level of the atrioventricular node. Studies with autonomic drugs indicate that this central nervous system control of VR in this arrhythmia usually occurs through activation of efferent cholinergic pathways.

Original languageEnglish (US)
Title of host publicationSEMIN.PSYCHIAT.
Pages461-474
Number of pages14
Volume5
Edition4
StatePublished - 1973

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Atrial Fibrillation
Autonomic Agents
Statistical Distributions
Efferent Pathways
Rheumatic Heart Disease
Atrioventricular Node
Ventricular Premature Complexes
Digitalis
Propranolol
Adrenergic Agents
Cholinergic Agents
Cardiac Arrhythmias
Central Nervous System

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bleecker, E. R., & Engel, B. T. (1973). Learned control of ventricular rate in patients with atrial fibrillation. In SEMIN.PSYCHIAT. (4 ed., Vol. 5, pp. 461-474)

Learned control of ventricular rate in patients with atrial fibrillation. / Bleecker, E. R.; Engel, B. T.

SEMIN.PSYCHIAT.. Vol. 5 4. ed. 1973. p. 461-474.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bleecker, ER & Engel, BT 1973, Learned control of ventricular rate in patients with atrial fibrillation. in SEMIN.PSYCHIAT.. 4 edn, vol. 5, pp. 461-474.
Bleecker ER, Engel BT. Learned control of ventricular rate in patients with atrial fibrillation. In SEMIN.PSYCHIAT.. 4 ed. Vol. 5. 1973. p. 461-474
Bleecker, E. R. ; Engel, B. T. / Learned control of ventricular rate in patients with atrial fibrillation. SEMIN.PSYCHIAT.. Vol. 5 4. ed. 1973. pp. 461-474
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