TY - JOUR
T1 - Lean Mass Predicts Hip Geometry in Men and Women With Non-Insulin-Requiring Type 2 Diabetes Mellitus
AU - Moseley, Kendall F.
AU - Dobrosielski, Devon A.
AU - Stewart, Kerry J.
AU - Sellmeyer, Deborah E.
AU - Jan De Beur, Suzanne M.
N1 - Funding Information:
The data presented in the manuscript are from the SHAPE-2 study, which was conducted at Johns Hopkins Bayview Medical Center and is supported by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases ( NCT00212303 , ClinicalTrials.gov ). The first author is supported by a grant from the National Institute on Aging ( 5T32 AG000120 , ClinicalTrials.gov ). No potential conflicts of interest relevant to this article were reported.
PY - 2011/7
Y1 - 2011/7
N2 - Persons with type 2 diabetes mellitus (T2DM) are at increased risk for hip fracture despite normal bone mineral density (BMD). The contribution of body composition to hip geometry, a measure of hip strength, has not been studied in T2DM. We hypothesized that lean mass would predict hip geometry. Subjects (n=134) for this cross-sectional analysis were men and women aged 56±6yr with non-insulin-requiring T2DM. Fat and lean mass were measured with dual-energy X-ray absorptiometry (DXA). Abdominal fat was measured with magnetic resonance imaging. Hip geometry parameters including section modulus, cross-sectional area, and buckling ratio were estimated from DXA using validated formulae. Subjects had normal BMD, elevated body mass indices (29-41kg/m2), and controlled T2DM (hemoglobin A1c: 5.1-8.3%). In bivariate analysis, lean mass was positively associated with section modulus and cross-sectional area in both sexes (r=0.36-0.55, p<0.05). In multivariate analyses, lean mass remained a significant predictor of all hip strength estimates in both sexes. In women alone, fat mass predicted parameters of hip strength. These data demonstrate that lean mass is significantly associated with hip strength in subjects with non-insulin-requiring T2DM. Resistance exercises that build lean mass may be an intervention for hip fracture prevention in T2DM, although additional research is needed.
AB - Persons with type 2 diabetes mellitus (T2DM) are at increased risk for hip fracture despite normal bone mineral density (BMD). The contribution of body composition to hip geometry, a measure of hip strength, has not been studied in T2DM. We hypothesized that lean mass would predict hip geometry. Subjects (n=134) for this cross-sectional analysis were men and women aged 56±6yr with non-insulin-requiring T2DM. Fat and lean mass were measured with dual-energy X-ray absorptiometry (DXA). Abdominal fat was measured with magnetic resonance imaging. Hip geometry parameters including section modulus, cross-sectional area, and buckling ratio were estimated from DXA using validated formulae. Subjects had normal BMD, elevated body mass indices (29-41kg/m2), and controlled T2DM (hemoglobin A1c: 5.1-8.3%). In bivariate analysis, lean mass was positively associated with section modulus and cross-sectional area in both sexes (r=0.36-0.55, p<0.05). In multivariate analyses, lean mass remained a significant predictor of all hip strength estimates in both sexes. In women alone, fat mass predicted parameters of hip strength. These data demonstrate that lean mass is significantly associated with hip strength in subjects with non-insulin-requiring T2DM. Resistance exercises that build lean mass may be an intervention for hip fracture prevention in T2DM, although additional research is needed.
KW - Body composition
KW - Bone density
KW - Hip geometry
KW - Type 2 diabetes
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U2 - 10.1016/j.jocd.2011.04.007
DO - 10.1016/j.jocd.2011.04.007
M3 - Article
C2 - 21652249
AN - SCOPUS:79960923448
VL - 14
SP - 332
EP - 339
JO - Journal of Clinical Densitometry
JF - Journal of Clinical Densitometry
SN - 1094-6950
IS - 3
ER -