TY - JOUR
T1 - Leading-edge research
T2 - PtdIns(3,4,5)P3 and directed migration
AU - Franca-Koh, Jonathan
AU - Kamimura, Yoichiro
AU - Devreotes, Peter N.
PY - 2007/1
Y1 - 2007/1
N2 - New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P3 in directional sensing.
AB - New studies reveal the dynamic accumulation of phosphatidylinositol (3,4,5) trisphosphate (PtdIns(3,4,5)P3) at the leading edge of primary neutrophils during chemotaxis. They also demonstrate that SHIP1, rather than phosphatase and tensin homologue (PTEN), is responsible for the degradation and localization of this lipid in neutrophils and shed light on the role of PtdIns(3,4,5)P3 in directional sensing.
UR - http://www.scopus.com/inward/record.url?scp=33845873342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845873342&partnerID=8YFLogxK
U2 - 10.1038/ncb0107-15
DO - 10.1038/ncb0107-15
M3 - Article
C2 - 17199126
AN - SCOPUS:33845873342
SN - 1465-7392
VL - 9
SP - 15
EP - 17
JO - Nature cell biology
JF - Nature cell biology
IS - 1
ER -