TY - JOUR
T1 - Lead poisoning
T2 - Altered urinary catecholamine metabolites as indicators of intoxication in mice and children
AU - Silbergeld, Ellen K.
AU - Chisolm, J. Julian
PY - 1976
Y1 - 1976
N2 - Whether neuropsychological impairment occurs in children with increased lead absorption who are without clinical symptoms is of current concern. This issue, which involves potentially large numbers of children, remains unresolved, in part because of the lack of sensitive biochemical indicators of the effects of lead on the nervous sytem. In experimental subclinical lead poisoning in mice, significant increases in homovanillic acid and vanillylmandelic acid have been found in brain and urine. In children with increased lead absorption, these acids were measured in urine collected quantitatively under controlled dietary conditions; preliminary results show fivefold increases in the daily output of these compounds. These data suggest that the altered catecholamine metabolism also occurs in children.
AB - Whether neuropsychological impairment occurs in children with increased lead absorption who are without clinical symptoms is of current concern. This issue, which involves potentially large numbers of children, remains unresolved, in part because of the lack of sensitive biochemical indicators of the effects of lead on the nervous sytem. In experimental subclinical lead poisoning in mice, significant increases in homovanillic acid and vanillylmandelic acid have been found in brain and urine. In children with increased lead absorption, these acids were measured in urine collected quantitatively under controlled dietary conditions; preliminary results show fivefold increases in the daily output of these compounds. These data suggest that the altered catecholamine metabolism also occurs in children.
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U2 - 10.1126/science.1257763
DO - 10.1126/science.1257763
M3 - Article
C2 - 1257763
AN - SCOPUS:0017227158
SN - 0036-8075
VL - 192
SP - 153
EP - 155
JO - Science
JF - Science
IS - 4235
ER -