Lead induced testicular hypersensitivity in stressed rats

D. K. Saxena, Bachchu Lal, R. S. Srivastava, S. V. Chandra

Research output: Contribution to journalArticle

Abstract

Rats were immobilized for 2 h and treated i.p. with lead Pb2+ (8 mg/kg/day) for 45 d to investigate the testicular effects of lead on rats kept under immobilization stress. Marked alteration in SDH, G6PDH activity, cholesterol and ascorbic acid contents and reduced sperm counts associated with marked pathological changes in the testis of rats were observed after combined treatment with lead and immobilization stress in comparison to either alone. An increase in the disturbance of testicular androgen synthesis seems to be responsible for enhanced testicular injury in lead induced stressed rats.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalExperimental Pathology
Volume39
Issue number2
StatePublished - 1990
Externally publishedYes

Fingerprint

Rats
Hypersensitivity
Immobilization
Sperm Count
Androgens
Ascorbic Acid
Testis
Cholesterol
Lead
Wounds and Injuries

Keywords

  • hypersensitivity, testicular
  • immobilization
  • Lead
  • stress
  • testicular hypersensitivity
  • testis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Saxena, D. K., Lal, B., Srivastava, R. S., & Chandra, S. V. (1990). Lead induced testicular hypersensitivity in stressed rats. Experimental Pathology, 39(2), 103-109.

Lead induced testicular hypersensitivity in stressed rats. / Saxena, D. K.; Lal, Bachchu; Srivastava, R. S.; Chandra, S. V.

In: Experimental Pathology, Vol. 39, No. 2, 1990, p. 103-109.

Research output: Contribution to journalArticle

Saxena, DK, Lal, B, Srivastava, RS & Chandra, SV 1990, 'Lead induced testicular hypersensitivity in stressed rats', Experimental Pathology, vol. 39, no. 2, pp. 103-109.
Saxena DK, Lal B, Srivastava RS, Chandra SV. Lead induced testicular hypersensitivity in stressed rats. Experimental Pathology. 1990;39(2):103-109.
Saxena, D. K. ; Lal, Bachchu ; Srivastava, R. S. ; Chandra, S. V. / Lead induced testicular hypersensitivity in stressed rats. In: Experimental Pathology. 1990 ; Vol. 39, No. 2. pp. 103-109.
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