Lead induced testicular hypersensitivity in stressed rats

D. K. Saxena; B. Lal; R. S. Srivastava; S. V. Chandra

doi:10.1016/S0232-1513(11)80169-6

Lead induced testicular hypersensitivity in stressed rats

D. K. Saxena, B. Lal, R. S. Srivastava, S. V. Chandra

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Rats were immobilized for 2 h and treated i.p. with lead Pb²⁺ (8 mg/kg/day) for 45 d to investigate the testicular effects of lead on rats kept under immobilization stress. Marked alteration in SDH, G6PDH activity, cholesterol and ascorbic acid contents and reduced sperm counts associated with marked pathological changes in the testis of rats were observed after combined treatment with lead and immobilization stress in comparison to either alone. An increase in the disturbances of testicular androgen synthesis seems to be responsible for enhanced testicular injury in lead induced stressed rats.

Original language	English (US)
Pages (from-to)	103-109
Number of pages	7
Journal	Experimental Pathology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/S0232-1513(11)80169-6
State	Published - 1990
Externally published	Yes

Keywords

hypersensitivity, testicular
immobilization
lead
stress
testicular hypersensitivity
testis

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/S0232-1513(11)80169-6

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title = "Lead induced testicular hypersensitivity in stressed rats",

abstract = "Rats were immobilized for 2 h and treated i.p. with lead Pb2+ (8 mg/kg/day) for 45 d to investigate the testicular effects of lead on rats kept under immobilization stress. Marked alteration in SDH, G6PDH activity, cholesterol and ascorbic acid contents and reduced sperm counts associated with marked pathological changes in the testis of rats were observed after combined treatment with lead and immobilization stress in comparison to either alone. An increase in the disturbances of testicular androgen synthesis seems to be responsible for enhanced testicular injury in lead induced stressed rats.",

keywords = "hypersensitivity, testicular, immobilization, lead, stress, testicular hypersensitivity, testis",

author = "Saxena, {D. K.} and B. Lal and Srivastava, {R. S.} and Chandra, {S. V.}",

year = "1990",

doi = "10.1016/S0232-1513(11)80169-6",

language = "English (US)",

volume = "39",

pages = "103--109",

journal = "Experimental Pathology",

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T1 - Lead induced testicular hypersensitivity in stressed rats

AU - Saxena, D. K.

AU - Lal, B.

AU - Srivastava, R. S.

AU - Chandra, S. V.

PY - 1990

Y1 - 1990

N2 - Rats were immobilized for 2 h and treated i.p. with lead Pb2+ (8 mg/kg/day) for 45 d to investigate the testicular effects of lead on rats kept under immobilization stress. Marked alteration in SDH, G6PDH activity, cholesterol and ascorbic acid contents and reduced sperm counts associated with marked pathological changes in the testis of rats were observed after combined treatment with lead and immobilization stress in comparison to either alone. An increase in the disturbances of testicular androgen synthesis seems to be responsible for enhanced testicular injury in lead induced stressed rats.

AB - Rats were immobilized for 2 h and treated i.p. with lead Pb2+ (8 mg/kg/day) for 45 d to investigate the testicular effects of lead on rats kept under immobilization stress. Marked alteration in SDH, G6PDH activity, cholesterol and ascorbic acid contents and reduced sperm counts associated with marked pathological changes in the testis of rats were observed after combined treatment with lead and immobilization stress in comparison to either alone. An increase in the disturbances of testicular androgen synthesis seems to be responsible for enhanced testicular injury in lead induced stressed rats.

KW - hypersensitivity, testicular

KW - immobilization

KW - lead

KW - stress

KW - testicular hypersensitivity

KW - testis

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DO - 10.1016/S0232-1513(11)80169-6

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AN - SCOPUS:0025334876

SN - 0232-1513

VL - 39

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EP - 109

JO - Experimental Pathology

JF - Experimental Pathology

IS - 2

ER -

Lead induced testicular hypersensitivity in stressed rats

Abstract

Keywords

ASJC Scopus subject areas

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