Lead induced testicular hypersensitivity in stressed rats

D. K. Saxena, Bachchu Lal, R. S. Srivastava, S. V. Chandra

Research output: Contribution to journalArticle


Rats were immobilized for 2 h and treated i.p. with lead Pb2+ (8 mg/kg/day) for 45 d to investigate the testicular effects of lead on rats kept under immobilization stress. Marked alteration in SDH, G6PDH activity, cholesterol and ascorbic acid contents and reduced sperm counts associated with marked pathological changes in the testis of rats were observed after combined treatment with lead and immobilization stress in comparison to either alone. An increase in the disturbance of testicular androgen synthesis seems to be responsible for enhanced testicular injury in lead induced stressed rats.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalExperimental Pathology
Issue number2
Publication statusPublished - 1990
Externally publishedYes



  • hypersensitivity, testicular
  • immobilization
  • Lead
  • stress
  • testicular hypersensitivity
  • testis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Saxena, D. K., Lal, B., Srivastava, R. S., & Chandra, S. V. (1990). Lead induced testicular hypersensitivity in stressed rats. Experimental Pathology, 39(2), 103-109.