Lead activates calmodulin sensitive processes

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.

Original languageEnglish (US)
Pages (from-to)1001-1006
Number of pages6
JournalLife Sciences
Volume33
Issue number10
DOIs
StatePublished - Sep 5 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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