Lead activates calmodulin sensitive processes

Gary W. Goldstein; Diane Ar

doi:10.1016/0024-3205(83)90757-9

Lead activates calmodulin sensitive processes

Gary W. Goldstein, Diane Ar

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.

Original language	English (US)
Pages (from-to)	1001-1006
Number of pages	6
Journal	Life Sciences
Volume	33
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(83)90757-9
State	Published - Sep 5 1983
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(83)90757-9

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title = "Lead activates calmodulin sensitive processes",

abstract = "The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.",

author = "Goldstein, {Gary W.} and Diane Ar",

note = "Funding Information: This research was supported by grants from the National Institutes of Health (#ES02380) and the March of Dimes Birth Defects Foundation (#1-706).",

year = "1983",

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doi = "10.1016/0024-3205(83)90757-9",

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T1 - Lead activates calmodulin sensitive processes

AU - Goldstein, Gary W.

AU - Ar, Diane

N1 - Funding Information: This research was supported by grants from the National Institutes of Health (#ES02380) and the March of Dimes Birth Defects Foundation (#1-706).

PY - 1983/9/5

Y1 - 1983/9/5

N2 - The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.

AB - The effect of lead on two calcium sensitive processes was determined. Micromolar concentrations of lead successfully replaced calcium in the activation of calmodulin-sensitive phosphodiesterase and in the promotion of potassium loss from erythrocytes. Both actions of lead were blocked by trifluoperazine--an inhibitor of calmodulin function. We propose that some of the toxic effects of lead may be explained by its interaction with calmodulin.

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U2 - 10.1016/0024-3205(83)90757-9

DO - 10.1016/0024-3205(83)90757-9

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JO - Life Sciences

JF - Life Sciences

IS - 10

ER -

Lead activates calmodulin sensitive processes

Abstract

ASJC Scopus subject areas

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