Lattice theory approach to metastatic disease patterns in autopsied human patients: Application to metastatic neuroblastoma

G. William Moore, Grover M. Hutchins, Suzanne M. de la Monte

    Research output: Contribution to journalArticle

    Abstract

    It is recognized that subsets of some morphologically homogeneous tumors may have different metastatic distribution patterns. Lattice theory is a multidimensional generalization of the cube. If each autopsied patient is regarded as a 'snapshot' (lattice corner), then each lattice edge represents an event of metastatic spread. A 'minimum entry' construction program was applied to the 40 neuroblastoma patients with complete autopsies at The Johns Hopkins Hospital. This lattice has the inductive property that reconnecting a single pathway does not decrease its length. Subset patterns in patients identified by this method may have diagnostic and therapeutic significance.

    Original languageEnglish (US)
    Pages (from-to)91-102
    Number of pages12
    JournalPattern Recognition
    Volume18
    Issue number2
    DOIs
    Publication statusPublished - 1985

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    Keywords

    • Cancer metastases
    • Lattice theory
    • Neuroblastoma
    • Partially ordered set
    • Tree diagram

    ASJC Scopus subject areas

    • Computer Vision and Pattern Recognition
    • Signal Processing
    • Electrical and Electronic Engineering

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