Lateralized differences in iodine-123-IBZM uptake in the basal ganglia in asymmetric Parkinson's disease

M. B. Knable, D. W. Jones, R. Coppola, Thomas Hyde, Sam Lee Kan Sam Lee, J. Gorey, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

We used equilibrium analysis of SPECT data from patients with asymmetric Parkinson's disease to determine if lateralized differences in the striatal uptake of [123I]IBZM correlate with asymmetry in clinical findings and, by inference, with lateralized differences in the concentration of extracellular dopamine. Methods: Twelve patients with asymmetric clinical signs of idiopathic Parkinson's disease were injected with a bolus of [123I]IBZM, and multiple SPECT scans recorded the time course of radioligand uptake. The time integral method was used to estimate peak specific binding, so that a ratio of specific-to-nonspecific binding in the left and right striatum of each subject at equilibrium could be determined. Nine patients also had 99mTc-HMPAO SPECT scans which were examined for evidence of blood flow asymmetries. Results: Paired t-tests comparing [123I]IBZM uptake revealed significantly greater (mean = 7.3%) availability of dopamine-D2 receptors in the basel ganglia contralateral to maximal clinical signs. Differences in receptor availability correlated significantly with differences in every measure of the clinical assessment. No significant differences in regional cerebral blood flow between the two sides were observed with 99mTc-HMPAO. Conclusion: These results demonstrate the ability of [123I]IBZM SPECT to reveal clinically meaningful variations in striatal dopamine receptor availability in patients with asymmetric Parkinson's disease. The equilibrium analysis technique used to determine these findings is a simple and robust method of measuring relative receptor availability and may be useful in studying other illnesses where dysfunction of dopaminergic neurotransmission is suspected.

Original languageEnglish (US)
Pages (from-to)1216-1225
Number of pages10
JournalJournal of Nuclear Medicine
Volume36
Issue number7
StatePublished - 1995
Externally publishedYes

Fingerprint

Basal Ganglia
Single-Photon Emission-Computed Tomography
Iodine
Parkinson Disease
Technetium Tc 99m Exametazime
Corpus Striatum
Cerebrovascular Circulation
Dopamine D2 Receptors
Regional Blood Flow
Dopamine Receptors
Synaptic Transmission
Ganglia
Dopamine
3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide

Keywords

  • dopamine receptors
  • iodine-123-IBZM
  • Parkinson's disease
  • single-photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Lateralized differences in iodine-123-IBZM uptake in the basal ganglia in asymmetric Parkinson's disease. / Knable, M. B.; Jones, D. W.; Coppola, R.; Hyde, Thomas; Kan Sam Lee, Sam Lee; Gorey, J.; Weinberger, Daniel.

In: Journal of Nuclear Medicine, Vol. 36, No. 7, 1995, p. 1216-1225.

Research output: Contribution to journalArticle

Knable, M. B. ; Jones, D. W. ; Coppola, R. ; Hyde, Thomas ; Kan Sam Lee, Sam Lee ; Gorey, J. ; Weinberger, Daniel. / Lateralized differences in iodine-123-IBZM uptake in the basal ganglia in asymmetric Parkinson's disease. In: Journal of Nuclear Medicine. 1995 ; Vol. 36, No. 7. pp. 1216-1225.
@article{253e95759023445e8d56a90d7fd12b50,
title = "Lateralized differences in iodine-123-IBZM uptake in the basal ganglia in asymmetric Parkinson's disease",
abstract = "We used equilibrium analysis of SPECT data from patients with asymmetric Parkinson's disease to determine if lateralized differences in the striatal uptake of [123I]IBZM correlate with asymmetry in clinical findings and, by inference, with lateralized differences in the concentration of extracellular dopamine. Methods: Twelve patients with asymmetric clinical signs of idiopathic Parkinson's disease were injected with a bolus of [123I]IBZM, and multiple SPECT scans recorded the time course of radioligand uptake. The time integral method was used to estimate peak specific binding, so that a ratio of specific-to-nonspecific binding in the left and right striatum of each subject at equilibrium could be determined. Nine patients also had 99mTc-HMPAO SPECT scans which were examined for evidence of blood flow asymmetries. Results: Paired t-tests comparing [123I]IBZM uptake revealed significantly greater (mean = 7.3{\%}) availability of dopamine-D2 receptors in the basel ganglia contralateral to maximal clinical signs. Differences in receptor availability correlated significantly with differences in every measure of the clinical assessment. No significant differences in regional cerebral blood flow between the two sides were observed with 99mTc-HMPAO. Conclusion: These results demonstrate the ability of [123I]IBZM SPECT to reveal clinically meaningful variations in striatal dopamine receptor availability in patients with asymmetric Parkinson's disease. The equilibrium analysis technique used to determine these findings is a simple and robust method of measuring relative receptor availability and may be useful in studying other illnesses where dysfunction of dopaminergic neurotransmission is suspected.",
keywords = "dopamine receptors, iodine-123-IBZM, Parkinson's disease, single-photon emission computed tomography",
author = "Knable, {M. B.} and Jones, {D. W.} and R. Coppola and Thomas Hyde and {Kan Sam Lee}, {Sam Lee} and J. Gorey and Daniel Weinberger",
year = "1995",
language = "English (US)",
volume = "36",
pages = "1216--1225",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "7",

}

TY - JOUR

T1 - Lateralized differences in iodine-123-IBZM uptake in the basal ganglia in asymmetric Parkinson's disease

AU - Knable, M. B.

AU - Jones, D. W.

AU - Coppola, R.

AU - Hyde, Thomas

AU - Kan Sam Lee, Sam Lee

AU - Gorey, J.

AU - Weinberger, Daniel

PY - 1995

Y1 - 1995

N2 - We used equilibrium analysis of SPECT data from patients with asymmetric Parkinson's disease to determine if lateralized differences in the striatal uptake of [123I]IBZM correlate with asymmetry in clinical findings and, by inference, with lateralized differences in the concentration of extracellular dopamine. Methods: Twelve patients with asymmetric clinical signs of idiopathic Parkinson's disease were injected with a bolus of [123I]IBZM, and multiple SPECT scans recorded the time course of radioligand uptake. The time integral method was used to estimate peak specific binding, so that a ratio of specific-to-nonspecific binding in the left and right striatum of each subject at equilibrium could be determined. Nine patients also had 99mTc-HMPAO SPECT scans which were examined for evidence of blood flow asymmetries. Results: Paired t-tests comparing [123I]IBZM uptake revealed significantly greater (mean = 7.3%) availability of dopamine-D2 receptors in the basel ganglia contralateral to maximal clinical signs. Differences in receptor availability correlated significantly with differences in every measure of the clinical assessment. No significant differences in regional cerebral blood flow between the two sides were observed with 99mTc-HMPAO. Conclusion: These results demonstrate the ability of [123I]IBZM SPECT to reveal clinically meaningful variations in striatal dopamine receptor availability in patients with asymmetric Parkinson's disease. The equilibrium analysis technique used to determine these findings is a simple and robust method of measuring relative receptor availability and may be useful in studying other illnesses where dysfunction of dopaminergic neurotransmission is suspected.

AB - We used equilibrium analysis of SPECT data from patients with asymmetric Parkinson's disease to determine if lateralized differences in the striatal uptake of [123I]IBZM correlate with asymmetry in clinical findings and, by inference, with lateralized differences in the concentration of extracellular dopamine. Methods: Twelve patients with asymmetric clinical signs of idiopathic Parkinson's disease were injected with a bolus of [123I]IBZM, and multiple SPECT scans recorded the time course of radioligand uptake. The time integral method was used to estimate peak specific binding, so that a ratio of specific-to-nonspecific binding in the left and right striatum of each subject at equilibrium could be determined. Nine patients also had 99mTc-HMPAO SPECT scans which were examined for evidence of blood flow asymmetries. Results: Paired t-tests comparing [123I]IBZM uptake revealed significantly greater (mean = 7.3%) availability of dopamine-D2 receptors in the basel ganglia contralateral to maximal clinical signs. Differences in receptor availability correlated significantly with differences in every measure of the clinical assessment. No significant differences in regional cerebral blood flow between the two sides were observed with 99mTc-HMPAO. Conclusion: These results demonstrate the ability of [123I]IBZM SPECT to reveal clinically meaningful variations in striatal dopamine receptor availability in patients with asymmetric Parkinson's disease. The equilibrium analysis technique used to determine these findings is a simple and robust method of measuring relative receptor availability and may be useful in studying other illnesses where dysfunction of dopaminergic neurotransmission is suspected.

KW - dopamine receptors

KW - iodine-123-IBZM

KW - Parkinson's disease

KW - single-photon emission computed tomography

UR - http://www.scopus.com/inward/record.url?scp=0029035545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029035545&partnerID=8YFLogxK

M3 - Article

C2 - 7790947

AN - SCOPUS:0029035545

VL - 36

SP - 1216

EP - 1225

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 7

ER -