TY - JOUR
T1 - Laterality of amblyopia
AU - Repka, Michael
AU - Simons, Kurt
AU - Kraker, Raymond
N1 - Funding Information:
Publication of this study is supported by Grant EY011751 from the National Eye Institute , National Institutes of Health , Bethesda, Maryland to the Pediatric Eye Disease Investigator Group, and by private funding from Mr. and Mrs. Robert Feduniak (K.S.). The authors indicate no financial conflict of interest. Involved in conception and design (M.R., R.K., K.S.); Data collection (M.R., R.K.); Analysis and interpretation of data (M.R., R.K., K.S.); Provision of materials, patients, or resources (M.R., R.K.); Statistical expertise (R.K.); Obtaining funding (M.R., R.K.); Literature search (M.R., R.K., K.S.); Administrative, technical, or logistic support (M.R., R.K.); Writing the article (M.R., R.K., K.S.); Critical revision of the article (M.R., R.K., K.S.); and Final approval of the article (M.R., R.K., K.S.). The respective institutional review boards approved the protocol and Health Insurance Portability and Accountability Act-compliant informed consent forms. The protocol and informed consent forms were approved by the institutional review boards for each of the named authors, and the parent of each study patient gave written informed consent. Study oversight was provided by an independent data and safety monitoring committee. The studies from which these data were obtained are registered at www.clinicaltrials.gov (identifiers NCT00000170 , NCT00094744 , NCT00094679 , NCT00094692 , NCT00094614 , NCT00091923 , NCT00315198 , NCT00315302 , and NCT00315328 ).
PY - 2010/8
Y1 - 2010/8
N2 - Purpose: To determine the frequency of unilateral amblyopia in right versus left eyes among children younger than 18 years. Design: Analysis of data collected in randomized clinical trials conducted by the Pediatric Eye Disease Investigator Group. Methods: The laterality of the amblyopic eye was analyzed in 2635 subjects younger than 18 years who participated in 9 multicenter prospective, randomized treatment trials. Eligibility criteria for these clinical trials included unilateral amblyopia associated with strabismus, anisometropia, or both, with visual acuity between 20/40 and 20/400. Logistic regression was used to assess the association of baseline and demographic factors with the laterality of amblyopia. Results: Among subjects with anisometropic amblyopia (with or without strabismus), amblyopia was present more often in left than right eyes, with a relative prevalence of 59% in left eyes (95% confidence interval, 57% to 62%; P < .001 from a test of proportion, 50%). However, among subjects with strabismic-only amblyopia, there was no laterality predilection (relative prevalence of 50% in left eyes; 95% confidence interval, 47% to 54%; P = .94). Conclusions: Anisometropic amblyopia, with or without strabismus, occurs more often in left eyes than right eyes. This finding of amblyopia laterality may be related to microtropia, sighting dominance, or other forms of ocular dominance; developmental or neurological factors; laterality in the development of refractive error; or a combination thereof.
AB - Purpose: To determine the frequency of unilateral amblyopia in right versus left eyes among children younger than 18 years. Design: Analysis of data collected in randomized clinical trials conducted by the Pediatric Eye Disease Investigator Group. Methods: The laterality of the amblyopic eye was analyzed in 2635 subjects younger than 18 years who participated in 9 multicenter prospective, randomized treatment trials. Eligibility criteria for these clinical trials included unilateral amblyopia associated with strabismus, anisometropia, or both, with visual acuity between 20/40 and 20/400. Logistic regression was used to assess the association of baseline and demographic factors with the laterality of amblyopia. Results: Among subjects with anisometropic amblyopia (with or without strabismus), amblyopia was present more often in left than right eyes, with a relative prevalence of 59% in left eyes (95% confidence interval, 57% to 62%; P < .001 from a test of proportion, 50%). However, among subjects with strabismic-only amblyopia, there was no laterality predilection (relative prevalence of 50% in left eyes; 95% confidence interval, 47% to 54%; P = .94). Conclusions: Anisometropic amblyopia, with or without strabismus, occurs more often in left eyes than right eyes. This finding of amblyopia laterality may be related to microtropia, sighting dominance, or other forms of ocular dominance; developmental or neurological factors; laterality in the development of refractive error; or a combination thereof.
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U2 - 10.1016/j.ajo.2010.01.040
DO - 10.1016/j.ajo.2010.01.040
M3 - Article
C2 - 20451898
AN - SCOPUS:77955501270
SN - 0002-9394
VL - 150
SP - 270
EP - 274
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -