Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder

Godfrey D. Pearlson; David J. Garbacz; William R. Breakey; Hyo S. Ahn; J. Raymond DePaulo

doi:10.1016/0165-1781(84)90133-1

Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder

Godfrey D. Pearlson, David J. Garbacz, William R. Breakey, Hyo S. Ahn, J. Raymond DePaulo

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

Forty-six patients with schizophrenia or bipolar disorder and 46 individually matched normal volunteers underwent computed tomographic (CT) scans of the head. The ventricular-to-brain ratio was strongly associated with persistent unemployment and negative symptoms in both patient groups. Previous findings of relative lateral ventricular enlargement in a proportion of schizophrenic and bipolar patients were also replicated. Implications of the relationship between CT changes and chronic unemployment among the patients are discussed.

Original language	English (US)
Pages (from-to)	1-9
Number of pages	9
Journal	Psychiatry research
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(84)90133-1
State	Published - May 1984

Keywords

Computed tomography
bipolar illness
chronic unemployment
negative symptoms
schizophrenia
ventricular-to-brain ratio

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

Access to Document

10.1016/0165-1781(84)90133-1

Cite this

@article{a03308399e8446fc8548b5eda26e0db5,

title = "Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder",

abstract = "Forty-six patients with schizophrenia or bipolar disorder and 46 individually matched normal volunteers underwent computed tomographic (CT) scans of the head. The ventricular-to-brain ratio was strongly associated with persistent unemployment and negative symptoms in both patient groups. Previous findings of relative lateral ventricular enlargement in a proportion of schizophrenic and bipolar patients were also replicated. Implications of the relationship between CT changes and chronic unemployment among the patients are discussed.",

keywords = "Computed tomography, bipolar illness, chronic unemployment, negative symptoms, schizophrenia, ventricular-to-brain ratio",

author = "Pearlson, {Godfrey D.} and Garbacz, {David J.} and Breakey, {William R.} and Ahn, {Hyo S.} and DePaulo, {J. Raymond}",

note = "Funding Information: Acknowledgments. This researchw as supported by a Johns Hopkins University Institutional Research Grant (to G.D.P.). Computational assistancew as receivedf rom CLINFO sponsored by NIH Grant #5MOIRR35-20. The following persons helped with critical reviews of the manuscript: P.R. McHugh, R.G. Robinson, G. Nestadt, P.V. Rabins, and J.R. Lipsey.",

year = "1984",

month = may,

doi = "10.1016/0165-1781(84)90133-1",

language = "English (US)",

volume = "12",

pages = "1--9",

journal = "Psychiatry research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder

AU - Pearlson, Godfrey D.

AU - Garbacz, David J.

AU - Breakey, William R.

AU - Ahn, Hyo S.

AU - DePaulo, J. Raymond

N1 - Funding Information: Acknowledgments. This researchw as supported by a Johns Hopkins University Institutional Research Grant (to G.D.P.). Computational assistancew as receivedf rom CLINFO sponsored by NIH Grant #5MOIRR35-20. The following persons helped with critical reviews of the manuscript: P.R. McHugh, R.G. Robinson, G. Nestadt, P.V. Rabins, and J.R. Lipsey.

PY - 1984/5

Y1 - 1984/5

N2 - Forty-six patients with schizophrenia or bipolar disorder and 46 individually matched normal volunteers underwent computed tomographic (CT) scans of the head. The ventricular-to-brain ratio was strongly associated with persistent unemployment and negative symptoms in both patient groups. Previous findings of relative lateral ventricular enlargement in a proportion of schizophrenic and bipolar patients were also replicated. Implications of the relationship between CT changes and chronic unemployment among the patients are discussed.

AB - Forty-six patients with schizophrenia or bipolar disorder and 46 individually matched normal volunteers underwent computed tomographic (CT) scans of the head. The ventricular-to-brain ratio was strongly associated with persistent unemployment and negative symptoms in both patient groups. Previous findings of relative lateral ventricular enlargement in a proportion of schizophrenic and bipolar patients were also replicated. Implications of the relationship between CT changes and chronic unemployment among the patients are discussed.

KW - Computed tomography

KW - bipolar illness

KW - chronic unemployment

KW - negative symptoms

KW - schizophrenia

KW - ventricular-to-brain ratio

UR - http://www.scopus.com/inward/record.url?scp=0021243853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021243853&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(84)90133-1

DO - 10.1016/0165-1781(84)90133-1

M3 - Article

C2 - 6589656

AN - SCOPUS:0021243853

SN - 0165-1781

VL - 12

SP - 1

EP - 9

JO - Psychiatry research

JF - Psychiatry research

IS - 1

ER -

Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this