Lateral phase separation of lipids in plasma membranes: Effect of temperature on the mobility of membrane antigens

Valerie A. Petit, Michael Edidin

Research output: Contribution to journalArticlepeer-review

Abstract

Cooling populations of newly formed mouse human heterokaryons has effects on the intermixing of mouse and human surface antigens which indicate the occurrence of phase separations in membrane lipids. Antigen mixing, previously shown to be due to diffusion in the plane of the membrane, is retarded when cells are cooled from 37° to 21°C, but is then speeded by further cooling to 15°C. This result is in accord with observations on phase separations of lipids in artificial and bacterial membranes.

Original languageEnglish (US)
Pages (from-to)1183-1185
Number of pages3
JournalScience
Volume184
Issue number4142
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • General

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